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CORCYM Announces the First Patient Enrolled in MANTRA Study

CORCYM Announces the First Patient Enrolled in MANTRA Study
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New VARC-3 Definitions Provide a Road Map for Future Aortic Valve Research

April 23, 2021
The Valve Academic Research Consortium (VARC) has updated their standardized definitions of clinical endpoints for transcatheter and surgical aortic valve clinical trials, including bioprosthetic valve dysfunction and failure, structural complications, conduction disturbances, and repeat hospitalizations, among others.
Published this week in the
European Heart Journal and the
Journal of the American College of Cardiology, the VARC-3 update was adopted given the “rapid evolution of the field,” including the emergence of new complications, expanding clinical indications, and novel therapy strategies, according to the writing committee.
As aortic valve research moves into younger patients, as well as those with less advanced aortic stenosis, future trials be they head-to-head comparisons of TAVI devices, TAVI versus surgery, or even TAVI or surgery versus medical therapy will need standardized definitions for capturing appropriate endpoints ....

United States , Los Angeles , Sanjay Kaul , Vinod Thourani , Bayer Janssen , Bristol Myers Squibb , Valve Academic Research Consortium , Sinai Medical Center , American College Of Cardiology , Md Piedmont Heart Institute , Drug Administration , Phd Catholic University , Journal Of The American College Cardiology , Society Of Thoracic Surgeons , Md Morristown Medical Center , European Heart Journal , American College , Morristown Medical Center , Allegations Need , Cedars Sinai Medical Center , Piedmont Heart Institute , Thoracic Surgeons , Catholic University , Fourth Universal Definition , ஒன்றுபட்டது மாநிலங்களில் , லாஸ் ஏஞ்சல்ஸ் ,