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Jaguar Health Announces Completion of Investigator-Initiated Phase 2 HALT-D Study Evaluating Mytesi (Crofelemer) for Prevention and Prophylaxis of Diarrhea in Breast Cancer Patients

SLA Resin Market Research Report - Global Forecast to 2024 - Cumulative Impact for COVID-19 Recovery


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France General , San Antonio , United States , Dave Fredrickson , Daiichi Sankyo , Fabrice Andr , Daiichi Sankyos , Head Of Research , Daiichi Sankyo Company , Oncology Development , World Health Organization , European Commission , Clinical Development Program , Department Of Medical Oncology , Daiichi Sankyo Group , European Union , Daiichi Sankyo Company Ltd , European Medicines Agency , Professor Fabrice Andr , Medical Oncology , Gustave Roussy Cancer Campus , Antonio Breast Cancer , New England Journal , Gilles Gallant , Senior Vice President , Global Head ,

ENHERTU® Approved in the EU for the Treatment of HER2 Positive Metastatic Breast Cancer


Press release content from Business Wire. The AP news staff was not involved in its creation.
ENHERTU® Approved in the EU for the Treatment of HER2 Positive Metastatic Breast Cancer
January 20, 2021 GMT
Daiichi Sankyo Company, Limited
(hereafter, Daiichi Sankyo) and AstraZeneca’s ENHERTU ® (trastuzumab deruxtecan) has been granted conditional approval in the European Union (EU) as a monotherapy for the treatment of adult patients with unresectable or metastatic HER2 positive breast cancer who have received two or more prior anti-HER2 based regimens.
In Europe, approximately 531,000 cases of breast cancer in women are diagnosed annually, with an estimated one in five cases being HER2 positive. 1,2,3 The impact of the disease is significant, with breast cancer responsible for more than 141,000 deaths per year in Europe. 1 ....

France General , San Antonio , United States , Dave Fredrickson , Masashi Kawase , Daiichi Sankyo , Daiichi Sankyo Europe Gmb , Fabrice Andr , Melo Gagliato , Head Of Research , Daiichi Sankyo Company , Oncology Development , Daiichi Sankyo Inc , European Commission , World Health Organization , Clinical Development Program , Daiichi Sankyo Co Ltd , Department Of Medical Oncology , Daiichi Sankyo Group , European Union , European Medicines Agency , Daiichi Sankyo Company Ltd , National Comprehensive Cancer Network , Sankyo Company , Professor Fabrice Andr , Medical Oncology ,

Clinical Challenges: Breast Cancer With Brain Metastasis


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Brain metastases are one of the most common and difficult-to-treat occurrences in metastatic breast cancer. They are found in 10% to 30% of patients. In patients with HER2-positive breast cancer, the rate of brain metastases is even higher up to 50%.
Initial treatments for brain metastases include locally directed therapy with surgical resection, stereotactic radiosurgery, and/or whole-brain radiation therapy. Unfortunately, the rate of intracranial progression with these therapies is high. Even more problematic, most systemic therapies have limited efficacy due to their inability to pass through the blood-brain barrier.
As patients live longer, they remain at risk for additional episodes of CNS [central nervous system] progression and/or new CNS metastases, Nancy Lin, MD, of the Dana-Farber Cancer Institute in Boston, told ....

United States , San Antonio , Dana Farber Cancer Institute , Nancy Lin , Eric Winer , Antonio Breast Cancer , ஒன்றுபட்டது மாநிலங்களில் , சான் அன்டோனியோ , டானா ஃபார்‌பர் புற்றுநோய் நிறுவனம் , நான்சி லின் , அன்டோனியோ மார்பக புற்றுநோய் ,

Add-On HDAC Inhibitor No Help in Breast Cancer


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Survival in advanced hormone receptor (HR)-positive breast cancer did not improve with the addition of a histone deacetylase (HDAC) inhibitor to standard endocrine therapy, according to a randomized trial.
Median progression-free survival (PFS) improved from 3.1 to 3.3 months and median overall survival (OS) from 21.7 to 23.4 months among patients who received entinostat plus the aromatase inhibitor (AI) exemestane. Neither difference reached statistical significance, despite a significant increase in lysine acetylation, which correlated in improved PFS in an earlier trial of the HDAC inhibitor.
The short median progression-free survival and low overall response rate observed with an endocrine therapy backbone suggests that improved decision-making tools are required to help determine who may need chemotherapy versus alternative strategies in this setting, reported Roisin M. Connolly, MD, of University College Cork in Ireland, at the San Antonio B ....

San Antonio , United States , Roisinm Connolly , Charles Bankhead , University College Cork , San Antonio Breast Cancer Symposium , Medpage Today , Antonio Breast Cancer , சான் அன்டோனியோ , ஒன்றுபட்டது மாநிலங்களில் , சார்லஸ் வங்கித் தலை , பல்கலைக்கழகம் கல்லூரி கார்க் , சான் அன்டோனியோ மார்பக புற்றுநோய் சிம்போசியம் , அன்டோனியோ மார்பக புற்றுநோய் ,