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Anesthesia doesn't simply turn off the brain — it changes its rhythms

May 12, 2021MIT
In a uniquely deep and detailed look at how the commonly used anesthetic propofol causes unconsciousness, a collaboration of labs at the Picower Institute for Learning and Memory at MIT shows that as the drug takes hold in the brain, a wide swath of regions become coordinated by very slow rhythms that maintain a commensurately languid pace of neural activity. Electrically stimulating a deeper region, the thalamus, restores synchrony of the brain’s normal higher frequency rhythms and activity levels, waking the brain back up and restoring arousal.
“There’s a folk psychology or tacit assumption that what anesthesia does is simply ‘turn off’ the brain,” says Earl Miller, Picower Professor of Neuroscience and co-senior author of the study in ....

United States , Meredith Mahnke , Andre Bastos , Josefina Correa , Jorge Yanar , Jefferson Roy , Earl Miller , Jacob Donoghue , Edward Hood Taplin , Scott Brincat , Emeryn Brown , Ayan Waite , Mikael Lundqvist , National Institutes Of Health , Picower Institute For , Picower Institute , Picower Professor , Edward Hood Taplin Professor , Medical Engineering , Computational Neuroscience , Massachusetts General , National Institutes , ஒன்றுபட்டது மாநிலங்களில் , ஆண்ட்ரே பாஸ்டோஸ் , ஜோசேபினா கொரியா , ஏர்ல் மில்லர் ,

Anesthesia doesn't simply turn off the brain — it changes its rhythms | MIT News | Massachusetts Institute of Technology

Caption:
Researchers measured how strongly brain waves were synchronized before, during, and after anesthesia with propofol. Data from the research shows strong increases in synchrony only in very slow frequencies (deep red color along bottom) between the thalamus and four cortical regions while animals were unconscious.
Credits:
Image courtesy of the Miller/Brown labs, Picower Institute
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In a uniquely deep and detailed look at how the commonly used anesthetic propofol causes unconsciousness, a collaboration of labs at the Picower Institute for Learning and Memory at MIT shows that as the drug takes hold in the brain, a wide swath of regions become coordinated by very slow rhythms that maintain a commensurately languid pace of neural activity. Electrically stimulating a deeper region, the thalamus, restores synchrony of the brain’s normal higher frequency rhythms ....

United States , Meredith Mahnke , Andre Bastos , Josefina Correa , Jorge Yanar , Jefferson Roy , Earl Miller , Jacob Donoghue , Edward Hood Taplin , Scott Brincat , Emeryn Brown , Ayan Waite , Mikael Lundqvist , National Institutes Of Health , Picower Institute For , Picower Institute , Picower Professor , Edward Hood Taplin Professor , Medical Engineering , Computational Neuroscience , Massachusetts General , National Institutes , ஒன்றுபட்டது மாநிலங்களில் , ஆண்ட்ரே பாஸ்டோஸ் , ஜோசேபினா கொரியா , ஏர்ல் மில்லர் ,

Anesthesia works by changing the brain's rhythms says new research -- Science of the Spirit -- Sott.net

Wed, 28 Apr 2021 09:20 UTC
Simultaneous measurement of neural rhythms and spikes across five brain areas in animals reveals how propofol induces unconsciousness.
In a uniquely deep and detailed look at how the commonly used anesthetic propofol causes unconsciousness, a collaboration of labs at The Picower Institute for Learning and Memory at MIT
shows that as the drug takes hold in the brain, a wide swath of regions become coordinated by very slow rhythms that maintain a commensurately languid pace of neural activity. Electrically stimulating a deeper region, the thalamus, restores synchrony of the brain s normal higher frequency rhythms and activity levels, waking the brain back up and restoring arousal. ....

United States , Meredith Mahnke , Andre Bastos , Josefina Correa , Jorge Yanar , Jefferson Roy , Earl Miller , Jacob Donoghue , Edward Hood Taplin , Scott Brincat , Emeryn Brown , Ayan Waite , Mikael Lundqvist , National Institutes Of Health , Picower Institute For , Picower Institute Data , Picower Institute , Picower Professor , Edward Hood Taplin Professor , Medical Engineering , Computational Neuroscience , Massachusetts General , National Institutes , ஒன்றுபட்டது மாநிலங்களில் , ஆண்ட்ரே பாஸ்டோஸ் , ஜோசேபினா கொரியா ,

Anesthesia doesn't simply turn off the brain, it changes its rhythms

Anesthesia doesn't simply turn off the brain, it changes its rhythms
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United States , Meredith Mahnke , Andre Bastos , Josefina Correa , Jorge Yanar , Jefferson Roy , Earl Miller , Jacob Donoghue , Edward Hood Taplin , Scott Brincat , Emeryn Brown , Ayan Waite , Mikael Lundqvist , National Institutes Of Health , Picower Institute For , Picower Institute , Picower Professor , Edward Hood Taplin Professor , Medical Engineering , Computational Neuroscience , Massachusetts General , National Institutes , ஒன்றுபட்டது மாநிலங்களில் , ஆண்ட்ரே பாஸ்டோஸ் , ஜோசேபினா கொரியா , ஏர்ல் மில்லர் ,

Brain waves guide us in spotlighting surprises

Caption:
Our ability to highlight surprises stems from a specific interplay of brain waves that suppress processing of predicted stimuli, such as the things we always see around the office, to pave the way for heightened processing of what s new, like a gift left on the desk one morning.
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If you open your office door one morning and there is a new package waiting on your desk, that’s what you will notice most in the otherwise unchanged room. A recent study by MIT and Boston University neuroscientists finds that the dynamic interplay of different brain wave frequencies, rather than dedicated circuitry, appears to govern the brain’s knack for highlighting what’s surprising and downplaying what’s predictable. ....

Nancy Kopell , Earl Miller , Mikael Lundqvist , Ayan Waite , Department Of Brain , Office Of Naval Research , National Institutes Of Mental Health , Proceedings Of The National Academy Sciences , Cognitive Sciences , Boston University , Picower Institute For , Picower Professor , National Academy , Picower Institute , William Fairfield Warren Distinguished Professor , National Institutes , Mental Health , Naval Research , Brain Waves , Brain Wave Frequencies , Alpha Waves , Beta Waves , Gamma Waves , Andre Bastos , Mit Brain And Cognitive Sciences , ஏர்ல் மில்லர் ,