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Alterations in the 3D genome structure and effects on fertility revealed


Credit: Covadonga Vara and Aurora Ruiz-Herrera, UAB.
The genome is tightly organised (packaged) within the cell nuclei. This three-dimensional (3D) genome organisation is fundamental, given that it regulates gene expression.
A study led by scientists at the Universitat Autònoma de Barcelona (UAB) now demonstrates using mice models that the 3D organisation of the genome is extremely dynamic during the formation of male germ cells (precursors of spermatozoa) and that alterations in this structure can affect fertility.
The research, published in
Nature Communications, describes the 3D genome organisation in germ cells of wild populations of house mice (Mus musculus domesticus) with chromosomal rearrangements, alterations in the genome which change the structure of chromosomes. The study represents a significant advance in research into mechanisms generating and regulating the structure and function of the genome during the formation of gametes (oocytes and sperm ....

Comunidad Autonoma De Cataluna , Covadonga Vara , Aurora Ruiz Herrera , Nature Communications , Department Of Cellular Biology , National Centre For Genomic Analysis , Centre For Genomic Regulation , Institute Of Biotechnology , Cornell University United States , Department Of Animal Biology , Universitat Aut , Associated Professor , Cellular Biology , Animal Biology , Plant Biology , National Centre , Genomic Analysis , Genomic Regulation , Sequentia Biotech , Cornell University , United States , Cell Biology , Developmental Reproductive Biology , காமுனிடட தன்னாட்சி டி கடலுள் , அரோரா ர்டீஸ் ஹெர்ரெரா , இயற்கை தகவல்தொடர்புகள் ,