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Tumor-promoting immune cells retrained to fight most aggressive type of brain cancer

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BOSTON - It s a real-life plot worthy of a classic spy novel: Researchers at Massachusetts General Hospital (MGH), the Dana-Farber Cancer Institute and other Boston-area research centers are turning the tables on glioblastomas, the most devastating and aggressive form of brain cancer, by transforming a type of cell that normally protects tumors and inhibits effective drug therapy into a stone-cold glioblastoma killer.
Glioblastoma, a type of brain tumor, is rapidly fatal: Most patients die within two years of diagnosis despite aggressive therapies such as brain surgery, whole-brain radiation and chemotherapy.
Despite hopes that a class of drugs known as immune checkpoint blockers (ICBs) - drugs that have revolutionized the treatment of patients with malignant melanoma, non-small-cell lung cancer, and other solid tumors - could also benefit patients with glioblastoma, ICBs have not been effective against the disease in clinical trials to date. ....

United States , Dana Farber Cancer Institute , Edwinl Steele , Rakeshk Jain , Hye Jung Kim , Zohreh Amoozgar , Dai Fukumura , Nature Communications , Jane Trust Foundation , National Institutes Of Health , Harvard Medical School , National Foundation For Cancer Research , Research Institute , Harvard Ludwig Cancer Center , Department Of Radiation Oncology , Research Foundation , Massachusetts General Hospital , Radiation Oncology , Andrew Werk Cook Professor , Dana Farber Cancer , National Institutes , National Foundation , Cancer Research , Advanced Medical Research Foundation , Harvard Medical , Mass General Research Institute ,

Exercise training may slow breast cancer growth by increasing anti-tumor immune response

Exercise training may slow breast cancer growth by increasing anti-tumor immune response
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United States , Igorl Gomes Santos , Edwinl Steele , Rakeshk Jain , Dai Fukumura , Emily Henderson , Cancer Immunology Research , Harvard Medical School , Department Of Radiation Oncology , Massachusetts General Hospital , Radiation Oncology , Steele Labs , Andrew Werk Cook Professor , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , புற்றுநோய் நோயெதிர்ப்பு ஆராய்ச்சி , ஹார்வர்ட் மருத்துவ பள்ளி , துறை ஆஃப் கதிர்வீச்சு புற்றுநோயியல் , மாசசூசெட்ஸ் ஜநரல் மருத்துவமனை , கதிர்வீச்சு புற்றுநோயியல் , ஆண்ட்ரூ வேர்க் சமைக்கவும் ப்ரொஃபெஸர் ,

Exercise benefit in breast cancer linked to improved immune responses

Physical exercise increases levels of cancer-fighting immune cells in animal models of breast cancer and slows the growth of tumors. In addition to lowering risk of developing cancer, structured exercise programs could help improve therapy for females with existing breast tumors. Exercise may also significantly improve treatment of breast cancer with immunotherapy drugs. ....

United States , Igorl Gomes Santos , Edwinl Steele , Rakeshk Jain , Dai Fukumura , Cancer Immunology Research , National Institutes Of Health To Fukumura , Sao Paulo Research Foundation Brazil , Jane Trust Foundation To Jain , Harvard Medical School , National Foundation For Cancer Research , Harvard Ludwig Cancer Center , Department Of Radiation Oncology , Research Foundation , Massachusetts General Hospital , Radiation Oncology , Steele Labs , Andrew Werk Cook Professor , National Institutes , National Foundation , Cancer Research , Advanced Medical Research Foundation , Trust Foundation , Sao Paulo Research Foundation , Medicine Health , Breast Cancer ,

Potential new treatment strategy for breast cancer cells that have spread to the brain

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BOSTON - New research reveals that when breast cancer cells spread to the brain, they must boost production of fatty acids, the building blocks of fat, in order to survive there. The work, which is published in
Nature Cancer and was led by investigators at Massachusetts General Hospital (MGH) and the Koch Institute of the Massachusetts Institute of Technology (MIT), points to a potential new treatment target for shrinking brain tumors that arise secondary to breast cancer.
Therapies that target the human epidermal growth factor receptor 2 (HER2) have transformed treatment for patients with breast cancer whose tumor cells express HER2, but brain metastases from this disease are typically fatal because they are resistant to anti-cancer therapies that are effective in other locations in the body. This is in part due to the blood-brain barrier that protects the brain against circulating toxins and pathogens, but changes in the cancer cells once they reach the bra ....

United States , Susang Komen , Gino Ferraro , Rakeshk Jain , Matthew Vander Heiden , Broad Institute , Jane Trust Foundation , Koch Institute , Alice Wallenberg Foundation , Ludwig Center At Harvard , National Science Foundation , Emerald Foundation , National Foundation For Cancer Research , Ludwig Center , Molecular Oncology Fund , Novo Nordisk Foundation , Research Foundation , Nature Cancer , Massachusetts General Hospital , Massachusetts Institute , Tumor Biology , Andrew Werk Cook Professor , Radiation Oncology , Harvard Medical , National Foundation , Cancer Research ,