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Researchers use AI to identify drugs that could be repurposed for Alzheimer's


Researchers use AI to identify drugs that could be repurposed for Alzheimer’s
Eli Lilly s JAK inhibitor Olumiant identified as a potential treatment for repurposing
Researchers from Harvard Medical School and Massachussetts General Hospital have revealed which drugs could be potentially repurposed as possible treatments for Alzheimer’s disease using artificial intelligence (AI).
The research team developed an AI-based method that enabled them to screen US Food and Drug Administration (FDA) approved medications for their potential as repurposed Alzheimer’s treatments.
The study, published in
Nature Communications, used a framework called DRIAD (Drug Repurposing in Alzheimer’s Disease) which uses machine learning to measure what happens to human brain neural cells when treated with a drug. ....

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AI reveals current drugs that may help combat Alzheimer's


AI reveals current drugs that may help combat Alzheimer’s
New treatments for Alzheimer’s disease are desperately needed, but numerous clinical trials of investigational drugs have failed to generate promising options. Now a team at Harvard-affiliated Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) has developed an artificial intelligence-based method to screen currently available medications as possible treatments for Alzheimer’s disease. The method could represent a rapid and inexpensive way to repurpose existing therapies into new treatments for this progressive, debilitating neurodegenerative condition. Importantly, it could also help reveal new, unexplored targets for therapy by pointing to mechanisms of drug action. ....

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