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T cells are not critical for recovery of primates from acute COVID-19 infections, study reveals


T cells are not critical for recovery of primates from acute COVID-19 infections, study reveals
New research conducted in monkeys reveals that T cells are not critical for the recovery of primates from acute COVID-19 infections. T cell depletion does not induce severe disease, and T cells do not account for the natural resistance of rhesus macaques to severe COVID-19. Furthermore, strongly T cell-depleted macaques still develop potent memory responses to a second infection.
The findings, published in the
mBio, an open-access journal of the American Society for Microbiology, have implications for the development of second-generation vaccines and therapeutics.
We started this study early in the pandemic, trying to figure out how to make a good model to study the disease in humans using animals. The monkeys turned out to be more resistant to the disease than we expected, so we wanted to try to figure out why that was and try to gain some insights into the disease in ....

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Study suggests T-cells don't determine survival in severe COVID-19


Study suggests T-cells don t determine survival in severe COVID-19
The coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes mild to moderate illness in the general population. Some people, however, may experience severe symptoms, which can be potentially fatal.
Severe COVID-19 has been tied to T cell lymphopenia, but no causal effect of T cell deficiency on disease severity has been established.
Researchers at the Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health found that T cell-depleted groups of rhesus macaques developed virus-neutralizing antibody responses and also class-switched to immunoglobulin G (IgG). ....

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