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Pandemic's mitigation efforts may have contributed to drop in clinical trial completion rates


Pandemic s mitigation efforts may have contributed to drop in clinical trial completion rates
Social distancing and lockdowns may have reduced the spread of COVID-19, but researchers from Penn State College of Medicine also report those actions may have affected clinical researchers ability to finish trials. Study completion rates dropped worldwide between 13% and 23%, depending on the type of research sponsor and geographic location, between April and October 2020.
Researchers previously reported that more than 80% of clinical trials suspended between March 1 and April 26, 2020, noted the pandemic as their chief reason for halting activity. Patient enrollment in studies was lower in April 2020, compared to April 2019. Arthur Berg, associate professor of public health sciences, and Nour Hawila, a biostatistics doctoral candidate, investigated how these trends may have affected the completion of clinical trials. ....

United States , Nour Hawila , Arthur Berg , Emily Henderson , Penn State Cancer Institute , Penn State College Of Medicine , Department Of Public Health Sciences , Penn State College , Research Assistant , Public Health , ஒன்றுபட்டது மாநிலங்களில் , ஆர்தர் பெர்க் , எமிலி ஹென்டர்சன் , பென் நிலை புற்றுநோய் நிறுவனம் , பென் நிலை கல்லூரி ஆஃப் மருந்து , துறை ஆஃப் பொது ஆரோக்கியம் அறிவியல் , பென் நிலை கல்லூரி , ஆராய்ச்சி உதவியாளர் , பொது ஆரோக்கியம் ,

Gene mutations linked to worse leukemia outcomes in Hispanic and Latino children


Gene mutations linked to worse leukemia outcomes in Hispanic and Latino children
A combination of genetic mutations may explain the higher incidence of and poorer outcomes from pediatric leukemia in Hispanic and Latino children, according to Penn State College of Medicine researchers. They said a novel therapeutic drug combination as well as testing for these mutations may help address the disparity.
Hispanic and Latino children are between 1.2 and 1.75 times more likely to develop B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, than non-Hispanic and Latino children. They also have a 40% higher death rate than their counterparts after correcting for socioeconomic factors. Dr. Sinisa Dovat, a researcher and pediatric oncologist at Penn State Children’s Hospital and Penn State Cancer Institute, partnered with Dr. Gordana Raca of Children’s Hospital Los Angeles and Kimberly J. Payne of Loma Linda University to understand the biol ....

Feng Yue , Yali Ding , Mark Reeves , Shriya Kane , Sinisa Dovat , Zissis Chroneos , Daniel Bogush , Joseph Schramm , Elanora Dovat , Los Angeles , Mary Mcgrath , Kimberlyj Payne , Hisham Abdel Azim , Dhimant Desai , Mario Soliman , Yiping Yang , Vladimir Spiegelman , Arati Sharma , Pavan Kumar Dhanyamraju , Arthur Berg , Jonathon Payne , Soumya Iyer , Gordana Raca , Deepa Bhojwani , Chandrika Gowda , Raghavendra Gowda ,

Gene mutations linked to worse outcomes from leukemia in Hispanic and Latino children


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A combination of genetic mutations may explain the higher incidence of and poorer outcomes from pediatric leukemia in Hispanic and Latino children, according to Penn State College of Medicine researchers. They said a novel therapeutic drug combination - as well as testing for these mutations - may help address the disparity.
Hispanic and Latino children are between 1.2 and 1.75 times more likely to develop B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, than non-Hispanic and Latino children. They also have a 40% higher death rate than their counterparts after correcting for socioeconomic factors. Dr. Sinisa Dovat, a researcher and pediatric oncologist at Penn State Children s Hospital and Penn State Cancer Institute, partnered with Dr. Gordana Raca of Children s Hospital Los Angeles and Kimberly J. Payne of Loma Linda University to understand the biology behind this health disparity after prior research suggested that there may be an ....

Feng Yue , Yali Ding , Mark Reeves , Shriya Kane , Sinisa Dovat , Zissis Chroneos , Daniel Bogush , Joseph Schramm , Elanora Dovat , Los Angeles , Mary Mcgrath , Kimberlyj Payne , Hisham Abdel Azim , Dhimant Desai , Mario Soliman , Yiping Yang , Vladimir Spiegelman , Arati Sharma , Pavan Kumar Dhanyamraju , Arthur Berg , Jonathon Payne , Soumya Iyer , Gordana Raca , Deepa Bhojwani , Chandrika Gowda , Raghavendra Gowda ,