ஆஸ்திரேலிய புற்றுநோய் ஆராய்ச்சி அடித்தளம் News Today : Breaking News, Live Updates & Top Stories | Vimarsana

Stay updated with breaking news from ஆஸ்திரேலிய புற்றுநோய் ஆராய்ச்சி அடித்தளம். Get real-time updates on events, politics, business, and more. Visit us for reliable news and exclusive interviews.

Top News In ஆஸ்திரேலிய புற்றுநோய் ஆராய்ச்சி அடித்தளம் Today - Breaking & Trending Today

Fundamental mechanism discovered that fine-tunes gene expression & is disrupted in cancer


Credit: The Wistar Institute
PHILADELPHIA and MELBOURNE, Australia (May. 17, 2021) A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription. As reported in a study published in
Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII). Disruption of this mechanism leads to unrestricted gene transcription and is implicated in cancer.
The study points to new viable opportunities for therapeutic intervention demonstrating the anti-cancer effect of a new combination treatment in preclinical models of solid and hematopoietic malignancies. ....

New York , United States , Dana Farber Cancer Institute , New South Wales , Benjamin Blyth , Otto Kauko , Jenniferr Devlin , Saraha Welsh , Elisa Barbieri , Kaylenej Simpson , Edwind Hawkins , Michael Ohlmeyer , Deboraha Knight , Matteo Costacurta , Stefan Bjelosevic , Gareth Gregory , Simonj Hogg , Ricky Johnstone , Elena Demosthenous , Magnus Zethoven , Jarrodj Sandow , Benp Martin , Conorj Kearney , Izabela Todorovski , Joseph Ha Vissers , Madisonj Kelly ,

New cellular atlas maps out healthy and cancerous breast tissue


Date Time
New cellular atlas maps out healthy and cancerous breast tissue
WEHI researchers have documented the diversity of cells in the human breast, explaining the relationship between healthy breast cells and breast cancer cells.
The diversity of cells in the human breast has been
documented in a new ‘RNA atlas’.
The research, which relied on expertise spanning from breast cancer biology through to bioinformatics, measured gene expression in single cells taken from healthy women and cancerous breast tissue, including tissue carrying a faulty BRCA1 gene. This enabled the researchers to create an ‘RNA atlas’ that details the different cells found in these tissues. ....

Tony Papenfuss , Jane Visvader , Geoff Lindeman , Gordon Smyth , Yunshun Chen , Rachel Joyce , Bhupinder Pal , Stephen Wilcox , Jocelyn Penington , Vanessa Bryant , Nina Tubau Ribera , Bianca Capaldo , National Health , Qualtrough Cancer Research Fund , Michael Heine Family Foundation , Ian Potter Foundation , Australian Cancer Research Foundation , National Breast Cancer Foundation , Research Council , Olivia Newton John Cancer Research Institute , Professor Jane Visvader , Professor Gordon Smyth , Professor Geoff , Professor Visvader , Professor Smyth , Victorian Cancer Biobank ,

The Directors: Toby Pike | LBBOnline


The Directors 75 Add to collection
FINCH director on being a designer turned director, his work for Sony and Audi and the reason he loves directing so much
FINCH s Toby Pike is a multidisciplinary designer and director working across commercial, music and installation projects. 
Through his award-winning career Toby has developed a truly unique, hyper-real aesthetic that merges film, technology, lighting, motion design and visual effects in a way that feels very human and emotionally engaging. 
Toby has been fortunate to work alongside some of Australia’s top music talent such as Flume, Chet Faker (Nick Murphy), Pnau, Flight Facilities, and Rufus. Internationally, he has worked with Brian Eno, Karl Hyde & Warp Records. Commercially, he has worked with such brands as Nike, Coke, Tiger Beer, Qantas, Disney, Star Wars, Pepsico, Google, HP, Lexus and The New York Art Directors Club.  ....

New York , United States , New South Wales , City Of , United Kingdom , Toby Love , Stephen Dupont , Toby Pike , Nick Murphy , Brian Eno , York Art Directors Club , Ableton Live School , Maritime Museum , London International , Australian Cancer Research Foundation , Toby Research , Chet Faker , Flight Facilities , Karl Hyde , Tiger Beer , Star Wars , New York Art Directors , London International Awards , Spikes Asia , Vimeo Staff , Sydney Festival ,

Freeze! Executioner protein caught in the act


 E-Mail
IMAGE: A cell in yellow is shown dying by necroptosis, a process requiring the protein MLKL
view more 
Credit: WEHI Australia
A new molecular freeze frame technique has allowed WEHI researchers to see key steps in how the protein MLKL kills cells.
Small proteins called monobodies were used to freeze MLKL at different stages as it moved from a dormant to an activated state, a key process that enables an inflammatory form of cell death called necroptosis. The team were able to map how the three-dimensional structure of MLKL changed, revealing potential target sites that might be targets for drugs - a potential new approach to blocking necroptosis as a treatment for inflammatory diseases. ....

Akiko Koide , Shohei Koide , Yanxiang Meng , James Murphy , Department Of Education , Engineering Postgraduate Research Award , Australian Institute Of Nuclear Science , Nature Communications , Melbourne Research Scholarship , Australian Government National Health , Australian Cancer Research Foundation , York University , Us National Institutes Of Health , Research Council , Associate Professor James Murphy , Assistant Professor Akiko Koide , Professor Shohei Koide , New York University , Professor Koide , Professor Murphy , Medical Research Council , Wendy Dowsett Scholarship , Australian Institute , Nuclear Science , Cell Biology , Medicine Health ,