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Cancer drug shows strong activity against SARS-CoV-2 in lab studies

Cancer drug shows strong activity against SARS-CoV-2 in lab studies
Updated Jan 29, 2021;
Posted Jan 29, 2021
FILE - This 2020 electron microscope image provided by the National Institute of Allergy and Infectious Diseases - Rocky Mountain Laboratories shows SARS-CoV-2 virus particles which cause COVID-19, isolated from a patient in the U.S., emerging from the surface of cells cultured in a lab. Viruses are constantly mutating, with coronavirus variants circulating around the globe. (NIAID-RML via AP)AP
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A report released on Jan. 25 by the University of California San Francisco, revealed that scientists at UC San Francisco’s Quantitative Bioscience Institute (QBI) and the Icahn School of Medicine at Mt. Sinai (ISMMS) in New York, have found that “a drug approved by the Australian Regulatory Agency for the treatment of multiple myeloma, has potent antiviral activity against SARS-CoV-2 - the virus that causes COVID-19.” ....

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Extract of Sea Squirt Shows Promise as COVID-19 Treatment

An extract from a rare undersea creature will soon be put to the test in clinical trials after initial studies showed effectiveness in stopping COVID-19. ....

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Cancer Drug Shows Potent Activity in the Lab Against SARS-CoV-2, Including New Variants

In two preclinical models of COVID-19, plitidepsin showed a 100-fold reduction in viral replication in the lungs and demonstrated an ability to reduce lung inflammation. ....

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Cancer Drug Shows Potent Activity in Lab Against SARS-CoV-2, Including B.1.1.7 Variant

Date Time
Cancer Drug Shows Potent Activity in Lab Against SARS-CoV-2, Including B.1.1.7 Variant
Plitidepsin was 27.5-fold more potent against SARS-CoV-2 than remdesivir, a drug that received FDA emergency use authorization in 2020 for the treatment of COVID-19, according to new research. Image by NIH
Scientists at UC San Francisco’s Quantitative Bioscience Institute (QBI) and the Icahn School of Medicine at Mt. Sinai (ISMMS) in New York have shown that plitidepsin (Aplidin), a drug approved by the Australian Regulatory Agency for the treatment of multiple myeloma, has potent antiviral activity against SARS-CoV-2, the virus that causes COVID-19.
In laboratory experiments reported in Science on Jan. 25, plitidepsin, a compound originally discovered in a Mediterranean sea squirt, was 27.5-fold more potent against SARS-CoV-2 than remdesivir, a drug that received FDA emergency use authorization in 2020 for the treatment of COVID-19. In addition, in two preclinical mo ....

New York , United States , South Africa , University College , New South Wales , South African , Kevan Shokat , Kris White , Nevan Krogan , Clare Jolly , Adolfo Garc , University College London , Uc San Francisco Quantitative Bioscience Institute , National Institute Of Allergy , Coronavirus Research Consortium , Centre For Integrative Biological Signalling Studies , National Institute Of Mental Health , Australian Regulatory Agency , Influenza Research , National Institutes Of Health , School Of Pharmacy , Pathogens Institute , Centers Of Excellence , Defense Advanced Research Projects Agency , Global Health , European Research Council ,

Cancer Drug Shows Potent Activity in Lab Against SARS-CoV-2, Including New Variants

Plitidepsin was 27.5-fold more potent against SARS-CoV-2 than remdesivir, a drug that received FDA emergency use authorization in 2020 for the treatment. ....

New York , United States , South Africa , University College , New South Wales , South African , Kevan Shokat , Kris White , Nevan Krogan , Clare Jolly , Adolfo Garc , University College London , Uc San Francisco Quantitative Bioscience Institute , National Institute Of Allergy , Coronavirus Research Consortium , Centre For Integrative Biological Signalling Studies , National Institute Of Mental Health , Australian Regulatory Agency , Influenza Research , National Institutes Of Health , School Of Pharmacy , Pathogens Institute , Centers Of Excellence , Defense Advanced Research Projects Agency , Global Health , European Research Council ,