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Frontiers | Review: Insights on Current FDA-Approved Monoclonal Antibodies Against Ebola Virus Infection

1 Abstract The devastating Ebola outbreak in West Africa in 2013-2016 accelerated the progress of several medical countermeasures (MCMs) against Ebola virus disease (EVD). Several IPs were used during that outbreak, but no conclusion on efficacy could be drawn. Only the Randomized Controlled Trial (RCT) on ZMapp was promising but inconclusive. More recently, during the second largest Ebola outbreak in North Kivu and Ituri provinces, Democratic Republic of the Congo (DRC), four IPs (Remdesivir, Regeneron, ZMapp and MAb114) have been evaluated in a RCT, the Pamoja Tulinde Maisha (PALM) study. Two products (Regeneron and MAb114) demonstrated efficacy as compared to the control arm, ZMapp. Very few side effects have been reported. Results from this scientifically sound study led the FDA to license both products, representing a milestone in EVD therapeutic field. These products can be produced relatively inexpensively and can be stockpiled. The administration of mAbs on EVD patients appears ....

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STA/Temporary: Complex Program Start-Up Operations Advisor - Goma, DRC


About Mercy Corps
Mercy Corps is a leading global organization powered by the belief that a better world is possible.
In disaster, in hardship, in more than 40 countries around the world, we partner to put bold solutions
into action helping people triumph over adversity and build stronger communities from within.
Now, and for the future.
Program / Department Summary
Mercy Corps has been operating in the Democratic Republic of the Congo (DRC) since August 2007, with a team member of around 450 people working in North and South Kivu and Ituri Provinces with the overall country goal to support vulnerable communities through crises, while fostering programs that build resilience and promote long-term change. Mercy Corps’ national office is in Goma with sub-field offices in North Kivu, South Kivu and Ituri Provinces. Mercy Corps’ key programming areas include a combination of longer-term development and immediate humanitarian response programs in order to: ....

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