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Compound may prevent risk of form of arrhythmia from common medications | The Source

Multi-institutional team combined expertise to make discovery
May 17, 2021
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Dozens of commonly used drugs, including antibiotics, anti-nausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart’s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these medications when taken in combination. ....

Jianmin Cui , Mira Cohen , Xiaoqin Zou , Institute For Data Science , Skandalaris Center , Institute Of Clinical , Entrepreneurial Acceleration Program , Office Of Technology Management , Washington University Office Of Technology Management , Translational Sciences , University Of Missouri , Research Innovation In Biotechnology , Proceedings Of The National Academy Sciences , Dalton Cardiovascular Research Center , Washington University In St , Institute For Molecular Cardiology , National Academy , Mckelvey School , Washington University , Distinguished Professor , Molecular Cardiology , Renaissance School , Stony Brook University , Data Science , Washington University Office , Technology Management ,

Researchers identify new compound that may prevent cardiac arrhythmia risk from common drugs

Researchers identify new compound that may prevent cardiac arrhythmia risk from common drugs
Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these medications when taken in combination. The team found that the compound, named C28, not only prevents or reverses the negative physiological effects on the action potential, ....

Jianmin Cui , Mira Cohen , Xiaoqin Zou , Emily Henderson , Institute For Data Science , Skandalaris Center , Office Of Technology Management , Institute Of Clinical , Entrepreneurial Acceleration Program , Washington University Office Of Technology Management , Translational Sciences , University Of Missouri , Research Innovation In Biotechnology , Proceedings Of The National Academy Sciences , Dalton Cardiovascular Research Center , Washington University In St , Institute For Molecular Cardiology , National Academy , Mckelvey School , Washington University , Distinguished Professor , Molecular Cardiology , Renaissance School , Stony Brook University , Data Science , Washington University Office ,

Compound may prevent risk of a form of arrhythmia from common medications

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IMAGE: Xiaoqin Zou, professor of physics, biochemistry, and a member of the Dalton Cardiovascular Research Center and Institute for Data Science and Informatics at the University of Missouri
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Credit: University of Missouri
Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these med ....

Jianmin Cui , Mira Cohen , Xiaoqin Zou , Institute For Data Science , Skandalaris Center , Institute Of Clinical , Entrepreneurial Acceleration Program , Office Of Technology Management , Washington University Office Of Technology Management , Translational Sciences , University Of Missouri , Research Innovation In Biotechnology , Proceedings Of The National Academy Sciences , Dalton Cardiovascular Research Center , Washington University In St , Institute For Molecular Cardiology , National Academy , Mckelvey School , Washington University , Distinguished Professor , Molecular Cardiology , Renaissance School , Stony Brook University , Data Science , Washington University Office , Technology Management ,

Resource Spotlight: Skandalaris I-Corps IGNITE and LAUNCH programs | WashU Fuse

The Skandalaris I-Corps program, through the National Science Foundation (NSF)
What is it?
The I-Corps IGNITE and LAUNCH programs provide experiential learning to researchers, innovators, and entrepreneurs seeking to translate their idea or technology into a viable company.
In
IGNITE, participating teams learn the foundations of customer discovery and how to develop a value proposition. The IGNITE curriculum prepares participants for the fall 2021 LAUNCH cohort.
LAUNCH is a more intense six-week program for “deep-tech” teams seeking to commercialize new technology or previous NSF-funded research. During the program, ten teams learn from industry mentors and each other through a simulated startup experience. The goal is to give potential founders the tools they’ll need to successfully launch their venture. ....

Washington University , United States , Mike Sepper , Skandalaris Center , National Science Foundation Innovation Corps , National Science Foundation , Washington University In St , Resource Spotlight , Skandalarisi Corps , Innovation Corps , Interdisciplinary Innovation , Corps Site , Missouris Ti Corps , Skandalarisi Corps Lead , Harris Stowe State University , வாஷிங்டன் பல்கலைக்கழகம் , மிச Ou ரி , ஒன்றுபட்டது மாநிலங்களில் , மைக் செப்பர் , தேசிய அறிவியல் அடித்தளம் கண்டுபிடிப்பு கார்ப்ஸ் , தேசிய அறிவியல் அடித்தளம் , வாஷிங்டன் பல்கலைக்கழகம் இல் ஸ்டம்ப் , வள ஸ்பாட்லைட் , கண்டுபிடிப்பு கார்ப்ஸ் , இடைநிலை கண்டுபிடிப்பு , கார்ப்ஸ் தளம் ,

The longest mile in the COVID-19 vaccine cold chain

The longest mile in the COVID-19 vaccine cold chain
Current COVID-19 vaccine candidates require storage at between eight and minus 80 degrees Celsius. Cold chain infrastructure in many developing countries struggles in the last mile . Copyright: UNICEF/Michael Tsegaye, (CC BY-NC-ND 2.0). This image has been cropped.
Speed read
Covering the ‘last mile’ of vaccine delivery remains big hurdle in COVID-19 battle
Better cold chain technology can prevent up to 25 per cent vaccine loss in poor countries
But rich nation ‘vaccine nationalism’ may undermine global delivery plans
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Sofiya Grad , Richard Hatchett , Luis Roman , Toby Peters , Hilde Stevens , Inga Vesper , Kostadin Fikiin , Haile Dooch , Institute For Interdisciplinary Innovation In Healthcare , Technical University Of Sofia , University Of Birmingham , Coalition For Epidemic Preparedness Innovations , Middle East , Technical University , Hamer District , Epidemic Preparedness Innovations , Interdisciplinary Innovation , சோஃபியா கிரத் , ரிச்சர்ட் ஹட்செட் , லூயிஸ் ரோமன் , டோபி பீட்டர்ஸ் , ஹில்ட் ஸ்டீவன்ஸ் , இங்க வெஸ்பர் , நிறுவனம் க்கு இடைநிலை கண்டுபிடிப்பு இல் சுகாதாரம் , தொழில்நுட்ப பல்கலைக்கழகம் ஆஃப் சோபியா , பல்கலைக்கழகம் ஆஃப் பர்மிங்காம் ,