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Transfer of SARS-CoV-2-specific antibodies through placenta

Recent analyses indicate that pregnant women and newborns may face elevated risks of developing more severe cases of COVID-19 following SARS-CoV-2 infection. ....

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Research reveals compromised transfer of SARS-CoV-2-specific antibodies through placenta

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BOSTON - Recent analyses indicate that pregnant women and newborns may face elevated risks of developing more severe cases of COVID-19 following SARS-CoV-2 infection. New research led by investigators at Massachusetts General Hospital (MGH) and published in
Cell reveals lower than expected transfer of protective SARS-CoV-2 antibodies via the placenta from mothers who are infected in the third trimester. The cause may be alterations to these antibodies after they re produced a process called glycosylation.
The results expand on the team s recent findings published in
JAMA Network Open that pregnant women with COVID-19 pass no SARS-CoV-2 virus, but also relatively low levels of antibodies against it, to newborns. For this latest study, the scientists compared maternal antibodies against the flu (influenza), whooping cough (pertussis), and SARS-CoV-2, and how these antibodies transferred across the placenta. Influenza- and pertussis-specific antibodies were ....

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Pregnant women with COVID-19 pass no virus but fewer-than-expected antibodies to newborns

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BOSTON Pregnant women may be especially vulnerable to developing more severe cases of COVID-19 following SARS-CoV-2 infection, but little is known about their anti-SARS-CoV-2 immune response or how it may affect their offspring. In a study published in
JAMA Network Open, a group led by investigators at Massachusetts General Hospital (MGH) provides new insights that could help improve care for these women and their newborns and emphasizes the need for pregnant women to be considered in vaccine rollout plans.
The study included 127 pregnant women in their third trimester who received care at three Boston hospitals between April 2 and June 13, 2020. Among the 64 women who tested positive for SARS-CoV-2, investigators detected no virus in maternal or cord blood (despite detection in the women s respiratory system), no signs of the virus in placentas and no evidence of viral transmission to newborns. The researchers suspect that transmission to the fetus may be ....

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Pregnant Women Serve as Primary Roll Out for COVID-19 Vaccination

Pregnant Women Serve as Primary Roll Out for COVID-19 Vaccination
by Karishma Abhishek on
December 23, 2020 at 12:00 AM
High vulnerability of pregnant women to develop severe SARS-CoV-2 infection - COVID-19 and the unknown potency of the anti-SARS-CoV-2 immune response in their offsprings, schedules the need to consider them for COVID-19 vaccination, as per a study at Massachusetts General Hospital (MGH), published in
JAMA Network Open.
127 pregnant women in their third trimester who received care at three Boston hospitals between April 2 and June 13, 2020, were included in the study. There were 64 women who tested positive for SARS-CoV-2, among which
no virus in maternal or cord blood or placentas (despite detection in the women s respiratory system), were detected. ....

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