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Could transforming alpha cells into beta cells treat diabetes?

Could transforming alpha cells into beta cells treat diabetes?
Written by James Kingsland on March 4, 2021 Fact checked by Rita Ponce, Ph.D.
New research in mice suggests a novel way to treat both forms of diabetes. 1130945222 Tom Werner/Getty Images
Scientists have used synthetic antibodies to block cell receptors in the liver that normally bind to glucagon, a hormone involved in increasing the amount of glucose in the blood.
The antibodies restored normal blood glucose levels in three different mouse models of diabetes.
The treatment partly worked by transforming alpha cells in the pancreas into insulin-producing beta cells.
The researchers believe that the same approach could treat type 1 and type 2 diabetes in people. ....

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Modifying Alpha Cells into Beta Cells Helps Treat Diabetes

Modifying Alpha Cells into Beta Cells Helps Treat Diabetes
by Angela Mohan on
March 2, 2021 at 12:29 PM
PNAS.
More than 34 million Americans have diabetes, a disease characterized by a loss of beta cells in the pancreas. Beta cells produce insulin, a hormone necessary for cells to absorb and use glucose, a type of sugar that circulates in the blood and serves as cellular fuel.
In Type 2 diabetes, the body s tissues develop insulin resistance, prompting beta cells to die from exhaustion from secreting excess insulin to allow cells to take in glucose.
In Type 1 diabetes, which affects about 10 percent of the diabetic population, beta cells die from an autoimmune attack. Both kinds of diabetes lead to severely elevated blood sugar levels that eventually cause a host of possible complications, including loss of limbs and eyesight, kidney damage, diabetic coma, and death. ....

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Study could offer a new way to treat Type 1 and Type 2 diabetes

Study could offer a new way to treat Type 1 and Type 2 diabetes
Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes by converting glucagon-producing cells into insulin producers instead, a team led by UT Southwestern reports in a new study. The findings, published online in
PNAS, could offer a new way to treat both Type 1 and Type 2 diabetes in people.
More than 34 million Americans have diabetes, a disease characterized by a loss of beta cells in the pancreas. Beta cells produce insulin, a hormone necessary for cells to absorb and use glucose, a type of sugar that circulates in the blood and serves as cellular fuel. ....

United States , Jyun Wang , Philippe Scherer , Williaml Holland , Emily Henderson , University Of Utah , Diabetes Research , Touchstone Center , May Yun Wang , Blood Sugar , Diabetic Coma , Insulin Resistance , Type 1 Diabetes , Type 2 Diabetes , ஒன்றுபட்டது மாநிலங்களில் , யுன் வாங் , பிலிப் ஸ்கிரெர் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் உட்டா , நீரிழிவு நோய் ஆராய்ச்சி , டச்ஸ்டோன் மையம் , இருக்கலாம் யுன் வாங் , நீரிழிவு நோய் , இரத்தம் சர்க்கரை , நீரிழிவு கோமா , இன்சுலின் எதிர்ப்பு ,

Swapping alpha cells for beta cells to treat diabetes

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IMAGE: At left is a healthy islet with many insulin-producing cells (green) and few glucagon-producing cells (red). At right, this situation is altered in a diabetic islet with a heavy preponderance.
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Credit: UT Southwestern Medical Center
Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes by converting glucagon-producing cells into insulin producers instead, a team led by UT Southwestern reports in a new study. The findings, published online in
PNAS, could offer a new way to treat both Type 1 and Type 2 diabetes in people.
More than 34 million Americans have diabetes, a disease characterized by a loss of beta cells in the pancreas. Beta cells produce insulin, a hormone necessary for cells to absorb and use glucose, a type of sugar that circulates in the blood and serves as cellular fuel. ....

United States , Derekc Leonard , Shangang Zhao , Eli Lilly , Williaml Holland , Young Lee , Rogerh Unger , Jyun Wang , Shiuhwei Chen , Ezekiel Quittner Strom , Philippe Scherer , Xinxin Yu , Yiyi Zhang , Zhuzhen Zhang , National Institute Of Diabetes , Kidney Human Islet Research Network , National Institutes Of Health , University Of Utah , Diabetes Research , Touchstone Center , Diabetes Research Foundation , Department Of Veterans Affairs , Touchstone Diabetes Center , May Yun Wang , Distinguished Chair , West Distinguished Chair ,