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A new international consortium to promote Stem Cell-Based Therapy for Huntington's disease


The Stem Cells for Huntington’s Disease (SC4HD) is a new international consortium created to promote
 advanced therapy medicinal product (ATMP) through cell transplantation studies on Huntington’s Disease. The entity, made up of twenty-eight renowned researchers from ten countries, has been officially presented in a recent publication in the
 J
ournal of Huntington’s Disease.
The main goals of SC4HD researchers are to work together with the HD community, develop criteria and guidance and address the main challenges to rapidly and safely bring potentially beneficial stem cell-based therapies to patients with this devastating disease. 
According to Josep M. Canals, director of Creatio and member of the steering committee of SC4HD, “there is an exciting opportunity to apply stem cell-based therapies in Huntington’s disease (HD), a devastating neurodegenerative disease that mainly affects neurons in the brain nucleus known as striatum”.  ....

Comunidad Autonoma De Cataluna , Validation Center , University Of Barcelona , Pii Sunyer Biomedical Research Institute , Biomedical Research Networking Center On Neurodegenerative Diseases , Department Of Biomedicine , Spanish Network Of Cell Therapy Tercel , Institute Of Neurosciences , Health Sciences , Stem Cell Based Therapy , Stem Cells , Biomedical Sciences , Advanced Therapies , Advanced Therapy Medicinal Products , Stem Cell , Biomedical Research Networking Center , Neurodegenerative Diseases , Sunyer Biomedical Research Institute , Spanish Network , Cell Therapy , காமுனிடட தன்னாட்சி டி கடலுள் , சரிபார்த்தல் மையம் , பல்கலைக்கழகம் ஆஃப் பார்சிலோனா , நிறுவனம் ஆஃப் நரம்பியல் , ஆரோக்கியம் அறிவியல் , தண்டு செல் அடிப்படையிலானது சிகிச்சை ,

New therapeutic target for Huntington's treatment


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IMAGE: From left to right: Mercè Masana, Ana Gámez-Valero, Eulàlia Martí, Anna Guisado-Corcoll, Esther Pérez-Navarro and Maria Solaguren-Beascoa.
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Credit: UNIVERSITY OF BARCELONA
Huntington s disease is caused by a mutation in the Huntingtin gene (HTT), which appears in adults and features motor, cognitive and psychiatric alterations. The origin of this disease has been associated with the anomalous functioning of the mutated protein: mHTT, but recent data showed the involvement of other molecular mechanisms.
A new study conducted by the University of Barcelona has identified a type of ribonucleic acid (RNA) as a potential therapeutic target for the treatment of the disease. These are the small RNA, or sRNAs, molecules that do not code proteins but have important functions in the regulation of gene expression. According to the study, sRNAs would take part in the development of the disease, results that shed light on the design ....

Comunidad Autonoma De Cataluna , Acta Neuropathologica , University Of Barcelona , University Medical Center , Health Sciences Eul , Biomedical Research Networking Center On Neurodegenerative Diseases , Institute Of Neurosciences , Pii Sunyer Biomedical Research Institute , Public Health Networking Biomedical Research Centre , Biomedical Research Networking Center , Neurodegenerative Diseases , Sunyer Biomedical Research Institute , Genomic Regulation , Medicine Health , Pharmaceutical Science , Gene Therapy , Disease In The Developing World , காமுனிடட தன்னாட்சி டி கடலுள் , பல்கலைக்கழகம் ஆஃப் பார்சிலோனா , பல்கலைக்கழகம் மருத்துவ மையம் , நிறுவனம் ஆஃப் நரம்பியல் , பொது ஆரோக்கியம் நெட்வொர்க்கிங் உயிர் மருத்துவ ஆராய்ச்சி மையம் , உயிர் மருத்துவ ஆராய்ச்சி நெட்வொர்க்கிங் மையம் , மருந்து ஆரோக்கியம் , மருந்து அறிவியல் , கீந் சிகிச்சை ,