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New Sensor Could Detect Real-Time Changes in Brain Serotonin Levels During Sleep, Fear

New Sensor Could Detect Real-Time Changes in Brain Serotonin Levels During Sleep, Fear
Written by AZoSensorsDec 24 2020
Serotonin is a neurochemical that plays a critical role in the way the brain controls our thoughts and feelings. For example, many antidepressants are designed to alter serotonin signals sent between neurons.
In an article in
Cell, National Institutes of Health-funded researchers described how they used advanced genetic engineering techniques to transform a bacterial protein into a new research tool that may help monitor serotonin transmission with greater fidelity than current methods. Preclinical experiments, primarily in mice, showed that the sensor could detect subtle, real-time changes in brain serotonin levels during sleep, fear, and social interactions, as well as test the effectiveness of new psychoactive drugs. The study was funded, in part, by the NIH s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative wh ....

United States , University Of California Davis , Johnj Ngai , Lorenl Looger , Edmund Ned Talley , Viviana Gradinaru , Us Department Of Energy Contract No , Howard Hughes Medical Institute Janelia Research Campus , Vector Engineering Research , Intramural Research Programs , Brain Research , Cellular Neuroscience Of The Chen Institute , University Of California Davis School Medicine , National Institute Of Mental Health , National Institute On Alcohol Abuse , Mistletoe Foundation , Beckman Institute , Heritage Medical Research Institute , Howard Hughes Medical Institute , National Institute Of Neurological Disorders , National Institutes , Advancing Innovative Neurotechnologies , Lin Tian , California Davis School , National Institute , Neurological Disorders ,

AI-Based Sensor may Help Detect Serotonin Levels During Sleep, Fear

AI-Based Sensor may Help Detect Serotonin Levels During Sleep, Fear
Written by AZoRoboticsDec 24 2020
Serotonin is a neurochemical that plays a critical role in the way the brain controls our thoughts and feelings. For example, many antidepressants are designed to alter serotonin signals sent between neurons.
In an article in
Cell, National Institutes of Health-funded researchers described how they used advanced genetic engineering techniques to transform a bacterial protein into a new research tool that may help monitor serotonin transmission with greater fidelity than current methods. Preclinical experiments, primarily in mice, showed that the sensor could detect subtle, real-time changes in brain serotonin levels during sleep, fear, and social interactions, as well as test the effectiveness of new psychoactive drugs. The study was funded, in part, by the NIH s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative which aims to revolu ....

United States , University Of California Davis , Johnj Ngai , Lorenl Looger , Edmund Ned Talley , Viviana Gradinaru , Us Department Of Energy Contract No , Howard Hughes Medical Institute Janelia Research Campus , Vector Engineering Research , Intramural Research Programs , Brain Research , Cellular Neuroscience Of The Chen Institute , University Of California Davis School Medicine , National Institute Of Mental Health , National Institute On Alcohol Abuse , Mistletoe Foundation , Beckman Institute , Heritage Medical Research Institute , Howard Hughes Medical Institute , National Institute Of Neurological Disorders , National Institutes , Advancing Innovative Neurotechnologies , Lin Tian , California Davis School , National Institute , Neurological Disorders ,

AI-designed serotonin sensor may help scientists study sleep and mental health

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IMAGE: NIH BRAIN Initiative-funded scientists used artificial intelligence to help redesign a nutrient grabbing, Venus flytrap-shaped bacterial protein into a highly sensitive serotonin sensor. Here the sensor captured for the first.
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Credit: Courtesy of Tian lab. University of California Davis School of Medicine.
Serotonin is a neurochemical that plays a critical role in the way the brain controls our thoughts and feelings. For example, many antidepressants are designed to alter serotonin signals sent between neurons. In an article in
Cell, National Institutes of Health-funded researchers described how they used advanced genetic engineering techniques to transform a bacterial protein into a new research tool that may help monitor serotonin transmission with greater fidelity than current methods. Preclinical experiments, primarily in mice, showed that the sensor could detect subtle, real-time changes in brain serotonin levels during s ....

United States , University Of California Davis , Johnj Ngai , Lorenl Looger , Edmund Ned Talley , Viviana Gradinaru , National Institute On Drug Abuse , Howard Hughes Medical Institute Janelia Research Campus , Vector Engineering Research , National Institute On , University Of California Davis School Medicine , National Institute Of Biomedical Imaging , National Institute Of Mental Health , National Eye Institute , Mistletoe Foundation , National Institute Of Neurological Disorders , Human Development , Us Department Of Energy Contract No , National Center , Us Department Of Health , Human Services , National Institutes Of Health , Intramural Research Programs , Brain Research , Cellular Neuroscience Of The Chen Institute , National Institute On Deafness ,