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Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests

Batch testing for SARS-CoV-2
Frequent and accurate RT-PCR–based testing is essential for preventing and managing SARS-CoV-2 infection; however, active infection surveillance is still often limited by time or resources. Cleary
et al. demonstrate that considering population-level viral prevalence and individual viral loads allows for efficiency gains upon pooled testing with minimal loss of sensitivity, both theoretically and as validated in vitro using human swab and sputum samples. Barak
et al. show that pooled testing of 133,816 hospital-collected patient nasopharyngeal samples eliminated three quarters of testing reactions with only a minor reduction in sensitivity, demonstrating the efficacy of the approach in the field. Both studies suggest that considered pooling of individual samples before testing could reliably increase SARS-CoV-2 testing throughput. ....

Hebrew University , Israel General , Ha Afon , Yutti Daitch , Irit Fogel , Gil Benedek , Danag Wolf , Roni Ben , T Miriam Rohrlich , Esther Oiknine Djian , Ayalah Livneh , E Chabube Kripper , Adi Sabatani , D Ben Zvi , Mila Rivkin , Hadassah Medical Center , Drug Administration , World Health Organization , Instrument Applied Biosystems Inc , Edmond De Rothschild Foundation Israel , Hebrew University Of Jerusalem , Laboratory Information System , Hadassah Medical Center Institutional Review Board , Emergency Use Authorizations , Hebrew University Hadassah , Pathogen Mini Kit ,

An Englishman, an Israeli, and a Palestinian Zoom into a call... | James Spiro

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President Shimon Peres in 2009 (Miriam Alster/Flash90)
Earlier this month, I had the pleasure of speaking to representatives at the Peres Center for Peace and Innovation on behalf of CTech for a piece I was working on. I had heard about one of their initiatives called ‘Starting Up Together’ from a colleague and I was inspired by its mission to help young Middle Eastern tech entrepreneurs from countries such as Egypt, Iraq, Morocco, The Palestinian Authority (Gaza), Syria, and Israel. ....

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