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Knopp Biosciences Reports Positive Results From the Phase 2 EXHALE Trial of Oral Dexpramipexole in Moderate-to-Severe Eosinophilic Asthma at ATS 2021


Knopp Biosciences Reports Positive Results From the Phase 2 EXHALE Trial of Oral Dexpramipexole in Moderate-to-Severe Eosinophilic Asthma at ATS 2021
05/17/2021 | 06:01am EDT
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Dexpramipexole was well tolerated, with 97% of drug-treated patients completing the primary assessment phase
Knopp Biosciences LLC today announced detailed results of its positive Phase 2 dose-ranging EXHALE trial of the novel oral eosinophil-lowering drug dexpramipexole in patients with moderate-to-severe asthma. The data were presented in a virtual poster session at the ATS 2021 International Conference.
The EXHALE trial was a randomized, double-blind, placebo-controlled study of dexpramipexole in patients with moderate-to-severe asthma and blood absolute eosinophil count (AEC) ≥300/µL. Dexpramipexole study drug at oral doses of 75 mg/day, 150 mg/day, or 300 mg/day was added to standard of care. The primary endpoint was change in AEC from Baseline to Week ....

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How Experts at Cincinnati Children's Hospital Medical Center Are Combatting Allergic Reactions


Cincinnati Magazine
January 6, 2021
Marc Rothenberg, M.D., directs the division of allergy and immunology and the Cincinnati Center for Eosinophilic Disorders at Cincinnati Children’s Hospital Medical Center. He’s spent decades trying to understand the mechanisms of allergic reactions, and his work has led to FDA approval for a drug that can help.
Illustration by Diana Bolton
It started about 32 years ago when I was a mere grad student and getting my PhD. In the lab, we discovered eosinophils, which are white blood cells, had a characteristic that causes them to grow and survive in ways that weren’t expected. ....

United States , Marc Rothenberg , Diana Bolton , Cincinnati Center , Eosinophilic Disorders , Cincinnati Children , Hospital Medical , ஒன்றுபட்டது மாநிலங்களில் , மார்க் ரோதன்பெர்க் , டயானா போல்டன் , ஸிந்ஸந்யாடீ மையம் , எயாஸிநொஃபிலிக் கோளாறுகள் , ஸிந்ஸந்யாடீ குழந்தைகள் , மருத்துவமனை மருத்துவ ,