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People from Mexico show stunning amount of genetic diversity

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Think local. Scientists have mapped the genetic relationships between Mexico’s indigenous groups and discovered a stunning amount of diversity.
A. Moreno-Estrada et al., Science (2014)
People from Mexico show stunning amount of genetic diversity
Jun. 12, 2014 , 2:00 PM
Imagine if people from Kansas and California were as genetically distinct from each other as someone from Germany is from someone from Japan. That’s the kind of remarkable genetic variation that scientists have now found within Mexico, thanks to the first fine-scale study of human genetic variation in that country. This local diversity could help researchers trace the history of the country’s different indigenous populations and help them develop better diagnostic tools and medical treatments for people of Mexican descent living all over the world. ....

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Diverse patient population helps identify gene variant associated with childhood asthma

Diverse patient population helps identify gene variant associated with childhood asthma
Researchers at Henry Ford Health System, as part of a national asthma collaborative, have identified a gene variant associated with childhood asthma that underscores the importance of including diverse patient populations in research studies.
The study is published in the print version of the
American Journal of Respiratory and Critical Care Medicine.
For 14 years researchers have known that a casual variant for early onset asthma resides on chromosome 17, which holds one of the most highly replicated and significant genetic associations with asthma. Henry Ford researchers acknowledged they would not have identified it in this study without a diverse patient population that included African Americans, many from the metro Detroit area. ....

United States , Hakon Hakonarson , Esteban Burchard , L Keoki Williams , Henry Ford , Emily Henderson , National Center , National Heart Lung , Genomic Medicine Research , Harvard Medical School , Blood Institute Trans , Henry Ford Health System , University Of California San Francisco , Researchers At Henry Ford Health System , Health Statistics , American Journal , Critical Care , African American , Keoki Williams , Study Senior Author , Henry Ford Health , Henry Ford Led , California San Francisco , Asthma Translational Genomics Collaborative , Blood Institute , Precision Medicine ,

Diversity among study participants credited with identifying gene linked to asthma

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IMAGE: L. Keoki Williams, M.D., MPH, the study s senior author and co-Director of Henry Ford Health System s Center for Individualized and Genomic Medicine Research.
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Credit: Henry Ford Health System
DETROIT (February 25, 2021) - Researchers at Henry Ford Health System, as part of a national asthma collaborative, have identified a gene variant associated with childhood asthma that underscores the importance of including diverse patient populations in research studies.
The study is published in the print version of the
American Journal of Respiratory and Critical Care Medicine.
For 14 years researchers have known that a casual variant for early onset asthma resides on chromosome 17, which holds one of the most highly replicated and significant genetic associations with asthma. Henry Ford researchers acknowledged they would not have identified it in this study without a diverse patient population that included African American ....

United States , Hakon Hakonarson , Esteban Burchard , Henry Ford Wyandotte , Henry Ford Macomb , L Keoki Williams , Henry Ford , National Institute Of Allergy , Health Alliance Plan , Henry Ford Medical Group , Trauma Center , Henry Ford Health System , University Of California San Francisco , American Asthma Foundation , Blood Institute , Researchers At Henry Ford Health System , National Center , National Institutes Of Health , National Heart Lung , Genomic Medicine Research , Harvard Medical School , Blood Institute Trans , Director Of Henry Ford Center , William Clay Ford Center , Henry Ford Allegiance Health In Jackson , Health Statistics ,

Minority Patients Miss Out On Life-Saving Cystic Fibrosis Drugs Due to Genetic Test Limitations

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Minority Patients Miss Out On Life-Saving Cystic Fibrosis Drugs Due to Genetic Test Limitations
There are many new drugs to treat cystic fibrosis, but non-white patients are effectively disqualified from receiving the latest precision medicines, accord to a new study. These drugs were approved by the U.S. Food and Drug Administration (FDA) for people with specific mutations, but non-white patients are more likely to carry different CF mutations. Because these other mutations aren’t included in genetic tests to qualify for the drugs, doctors cannot prescribe these new treatments for non-white patients, and insurance carriers won’t cover the cost. ....

Puerto Rico , United States , Puerto Rican , Esteban Burchard , Susannaa Mccolley , Meghan Mcgarry , Northwestern University Clinical , Cystic Fibrosis Foundation Therapeutics Lab , Drug Administration , Cystic Fibrosis Foundation , Northwestern University Feinberg School Of Medicine , Translational Sciences Institute , Blood Institute , National Heart , Pediatric Pulmonology , Northwestern University , Feinberg School , Cystic Fibrosis Foundation Therapeutics , Cystic Fibrosis , ப்வெர்டோ ரிக்கோ , ஒன்றுபட்டது மாநிலங்களில் , ப்வெர்டோ ரிக்கன் , எஸ்டெபாந் புர்ச்சார்ட் , மேகன் மக்யாரீ , வடமேற்கு பல்கலைக்கழகம் மருத்துவ , சிஸ்டிக் ஃபைப்ரோஸிஸ் அடித்தளம் சிகிச்சை ஆய்வகம் ,