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Researchers find possible cause for self-destructive immune system attacks in autoimmune diseases


Researchers find possible cause for self-destructive immune system attacks in autoimmune diseases
Autoimmune diseases, in which the body s own immune system attacks healthy tissue, can be life-threatening and can impact all organs. A research team at the Technical University of Munich (TUM) has now found a possible cause for these self-destructive immune system attacks: a hyperactive RANK protein on the surface of B cells. The research opens the door to new therapeutic possibilities.
The immune system can be a mixed blessing: Usually it is highly effective in protecting the human organism against bacteria, viruses and mycosis and even cancer. But these defense cells can also turn against the body s own tissues and trigger autoimmune diseases, including for example rheumatoid arthritis and systemic lupus erythematosus, an illness involving chronic dermatitis and inflammation of the joints, the nervous system and internal organs or even become cancer cells themselves and dev ....

Maike Buchner , Juergen Ruland , Emily Henderson , Technical University Of Munich , German Research Foundation , Institute Of Clinical Chemistry , Institute For Clinical Chemistry , Technical University , Clinical Chemistry , Research Foundation , Leibniz Prize , Receptor Activator , Autoimmune Disease , Immune System , Lupus Erythematosus , Nervous System , Rheumatoid Arthritis , Systemic Lupus Erythematosus , ஜூர்கன் ருளந்ட் , எமிலி ஹென்டர்சன் , தொழில்நுட்ப பல்கலைக்கழகம் ஆஃப் முனிச் , ஜெர்மன் ஆராய்ச்சி அடித்தளம் , நிறுவனம் ஆஃப் மருத்துவ வேதியியல் , நிறுவனம் க்கு மருத்துவ வேதியியல் , தொழில்நுட்ப பல்கலைக்கழகம் , மருத்துவ வேதியியல் ,

When hyperactive proteins trigger illnesses


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The immune system can be a mixed blessing: Usually it is highly effective in protecting the human organism against bacteria, viruses and mycosis and even cancer. But these defense cells can also turn against the body s own tissues and trigger autoimmune diseases, including for example rheumatoid arthritis and systemic lupus erythematosus, an illness involving chronic dermatitis and inflammation of the joints, the nervous system and internal organs or even become cancer cells themselves and develop into leukemias or lymphomas. But what causes these destructive immune system attacks?
The question has yet to be finally resolved, says Prof. Juergen Ruland, Director of the TUM Institute for Clinical Chemistry and Pathobiochemistry. B cells, a subgroup of white blood corpuscles produced in the bone marrow, play a central role in regulating immune responses. During a normal immune response, activated B cells produce antibodies which attack foreign substances. Defectiv ....

Maike Buchner , Juergen Ruland , German Research Foundation , Institute Of Clinical Chemistry , Institute For Clinical Chemistry , Clinical Chemistry , Research Foundation , Leibniz Prize , Receptor Activator , ஜூர்கன் ருளந்ட் , ஜெர்மன் ஆராய்ச்சி அடித்தளம் , நிறுவனம் ஆஃப் மருத்துவ வேதியியல் , நிறுவனம் க்கு மருத்துவ வேதியியல் , மருத்துவ வேதியியல் , ஆராய்ச்சி அடித்தளம் , ஏற்பி ஆக்டிவேட்டர் ,