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Study Shows Voluntary Running Reduces Neuromuscular Decline In Aging Mice


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Study Shows Voluntary Running Reduces Neuromuscular Decline In Aging Mice
Their study, published online in Neurobiology of Aging,investigated aging rodents that underwent voluntary running exercise between the ages of 22 and 27 months, which represents roughly 55 to 80 years of age in humans.
“These experiments showed that running significantly improved the neuromuscular decline in mice that underwent running compared to sedentary mice. Our findings support the mantra of ‘use it or lose it’ in regards to the connection between the nervous system and muscles, namely the neuromuscular junction,” said senior author Dr. W. David Arnold, neuromuscular specialist and associate professor at Ohio State Wexner Medical Center. ....

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Mouse study: gabapentin prevents harmful structural changes in spinal cord


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IMAGE: Phillip Popovich is a professor and chair of Ohio State s Department of Neuroscience and Executive Director of the Belford Center for Spinal Cord Injury at The Ohio State University College.
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Credit: The Ohio State University Wexner Medical Center
COLUMBUS, Ohio - Research led by The Ohio State University Wexner Medical Center and College of Medicine found that the widely prescribed pain-relief drug gabapentin can prevent harmful structural changes in the injured spinal cords of mice, and also block cardiovascular changes and immune suppression caused by spinal cord injury.
Gabapentin is often prescribed as a treatment for pain, but if it is given early after injury - before symptoms develop - it can also limit structural changes in nerve cells. We show that these benefits remain even one month after stopping gabapentin treatment in spinal injured mice. We believe that gabapentin could be repurposed as a prophylactic therap ....

United States , Rayw Poppleton , Phillip Popovich , Us Department Of Defense , Belford Center , National Institutes Of Health , Ohio State Department , Ohio State Department Of Neuroscience , Ohio State University Wexner Medical Center , Ohio State Neurological Institute , Craigh Neilsen Foundation , College Of Medicine , University Of California San Francisco , Ohio Department Of Higher Education , Duke University , Ohio State , Faith Brennan , Neurological Institute , Spinal Cord , California San Francisco , National Institutes , Ohio Department , ஒன்றுபட்டது மாநிலங்களில் , பிலிப் பொப்பொவிச் , எங்களுக்கு துறை ஆஃப் பாதுகாப்பு , பெல்ஃபோர்ட் மையம் ,