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Critical mechanism allows deadly bacteria to gain resistance to antibiotics

Critical mechanism allows deadly bacteria to gain resistance to antibiotics
Researchers have identified a critical mechanism that allows deadly bacteria to gain resistance to antibiotics.
The findings offer a potential new drug target in the search for effective new antibiotics as we face the growing threat of antimicrobial resistance (AMR) and infections caused by bacterial pathogens.
The study investigated quinolone antibiotics which are used to treat a range of bacterial infections, including TB (tuberculosis). Quinolones work by inhibiting bacterial enzymes, gyrase and topoisomerase IV, thereby preventing DNA replication and RNA synthesis essential to growth.
They are highly-successful antimicrobial agents widely used in current medicine, however bacterial resistance to them and other treatments is a serious problem. ....

Tony Maxwell , Emily Henderson , John Innes Centre , Professor Tony Maxwell , Study Corresponding Author , John Innes , Antimicrobial Resistance , Dna Replication , டோனி மேக்ஸ்வெல் , எமிலி ஹென்டர்சன் , ஜான் இநெஸ் மையம் , ப்ரொஃபெஸர் டோனி மேக்ஸ்வெல் , ஜான் இநெஸ் , ஆண்டிமைக்ரோபியல் எதிர்ப்பு , டீயெநே பிரதிசெய்கை ,

Coalition working to end gender-based sexual violence in Democratic Republic of Congo

UNAIDS
The Democratic Republic of the Congo has been plagued by political instability since the 1990s and has seen widespread attacks against civilians, violence between ethnic factions, rape and other forms of sexual violence, and murder. Sexual violence against adolescent girls and young women is common.
Violence against women and girls continues to be a global pandemic that affects one in three women in their life. Violence against women is a major factor for contracting HIV-in areas with a high HIV burden, such as sub-Saharan Africa, women subjected to intimate partner violence are 50% more likely to be living with HIV. And men who are perpetrators of violence against women tend to be at a higher risk of HIV themselves and to use condoms less frequently, thus increasing the risk of HIV transmission. ....

Democratic Republic Of The Congo , Nathalie Nyembwe , Susan Kasedde , Global Partnership For Action To , Global Fund To Fight , Democratic Republic , Saharan Africa , Health Survey , Global Fund , Global Partnership , Related Discrimination , Reproductive Health , Gender Equality , ஜனநாயக குடியரசு ஆஃப் தி காங்கோ , உலகளாவிய கூட்டு க்கு நடவடிக்கை க்கு , உலகளாவிய நிதி க்கு சண்டை , ஜனநாயக குடியரசு , ஆரோக்கியம் கணக்கெடுப்பு , உலகளாவிய நிதி , உலகளாவிய கூட்டு , தொடர்புடையது பாகுபாடு , இனப்பெருக்கம் ஆரோக்கியம் , ஜெஂடர் சமத்துவம் ,

Treating latent TB in rural China

Treating latent TB in rural China
All local recommended safety guidelines followed at the time of interview.
Every tenth new tuberculosis (TB) case occurs in China, making it the country with the third most cases globally. Tuberculosis is one of the top ten causes of death worldwide, but, it is also curable and preventable, which is the driving force behind Dr. Gao Lei and his team who are fighting to end TB at the source.
According to the latest statistical data, 833,000 people in China contracted tuberculosis in 2019, and more than 3,300 died from it. The prevalence of latent tuberculosis infection (LTBI) is known to be the greatest contributor towards spreading the disease, meaning that identification plays a key role in curbing and curing TB. But, to reach the global goal set by the World Health Organization (WHO) to eliminate tuberculosis by 2035, progress is still too slow. ....

Gao Lei , X Ray , கொ லீ , எக்ஸ் ராய் ,

How one patient's rare mutation helped solve a mycobacterial mystery

Just because you are exposed to a pathogen does not mean you will become sick. Increasingly, scientists have shown that genetics play a central role in. ....

Jean Laurent Casanova , Rockefeller University , Immune Response , Immune Cells , ஜீன் பரிசு பெற்றவர் காஸநோவா , ராக்ஃபெல்லர் பல்கலைக்கழகம் , நோய் எதிர்ப்பு சக்தி பதில் , நோய் எதிர்ப்பு சக்தி செல்கள் ,

Putting people at centre brings good results in Nigeria

Nigeria has demonstrated that putting people at the centre of the AIDS response works in advancing HIV service delivery. The 2018 Nigeria HIV/AIDS. ....

South Africa , United States , Gambo Aliyu , Bill Paul , Ibrahim Abdulkadir , Osagie Ehanire , Erasmus Morah , National Data Repository , Network Of People Living , Malaria Global Fund , Health Of Nigeria , Global Fund To Fight , National Alignment Strategy , Global Fund , Office Of The United States Global , Deputy Coordinator For Program Quality , National Coordinator , Co Ordination Agency , Impact Survey , United States President , Emergency Plan , People Living , Deputy Coordinator , Program Quality , United States Global , Community Engagement ,