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Proteins play crucial role in muscle growth

Proteins play crucial role in muscle growth
When a muscle grows, because its owner is still growing too or has started exercising regularly, some of the stem cells in this muscle develop into new muscle cells.
The same thing happens when an injured muscle starts to heal. At the same time, however, the muscle stem cells must produce further stem cells - i.e., renew themselves - as their supply would otherwise be depleted very quickly. This requires that the cells involved in muscle growth communicate with each other.
Muscle growth is regulated by the Notch signaling pathway
Two years ago, a team of researchers led by Professor Carmen Birchmeier, head of the Developmental Biology/Signal Transduction Lab at the Berlin-based Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), showed that the development of stem cells into muscle cells is regulated with the help of two proteins, Hes1 and MyoD, which are produced in the progenitor cells in an ....

Max Delbr , Jana Wolf , Carmen Birchmeier , Ines Lahmann , Yao Zhang , Katharina Baum , Emily Henderson , Nature Communications , Developmental Biology Signal Transduction Lab , Helmholtz Association , Professor Carmen Birchmeier , Signal Transduction Lab , Berlin Based Max Delbr , Molecular Medicine , Professor Jana Wolf , Developmental Biology , Notch Signaling , Progenitor Cells , Signaling Pathway , Stem Cells , ஜன ஓநாய் , கார்மென் பிர்ச்மியர் , யாவ் ஜாங் , காதரின பாம் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் ,

The key to proper muscle growth

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IMAGE: Immunofluorescence analysis of a group of proliferating stem cells associated with a muscle fiber (grey). The stem cells produce Dll1 (red) and MyoD (green). Two of the cells produces MyoG.
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Credit: Birchmeier Lab, MDC
When a muscle grows, because its owner is still growing too or has started exercising regularly, some of the stem cells in this muscle develop into new muscle cells. The same thing happens when an injured muscle starts to heal. At the same time, however, the muscle stem cells must produce further stem cells - i.e., renew themselves - as their supply would otherwise be depleted very quickly. This requires that the cells involved in muscle growth communicate with each other. ....

Max Delbr , Jana Wolf , Carmen Birchmeier , Ines Lahmann , Yao Zhang , Katharina Baum , Nature Communications , Helmholtz Association , Developmental Biology Signal Transduction Lab , Professor Carmen Birchmeier , Signal Transduction Lab , Berlin Based Max Delbr , Molecular Medicine , Professor Jana Wolf , Medicine Health , Developmental Reproductive Biology , ஜன ஓநாய் , கார்மென் பிர்ச்மியர் , யாவ் ஜாங் , காதரின பாம் , இயற்கை தகவல்தொடர்புகள் , வளர்ச்சி உயிரியல் சமிக்ஞை கடத்தல் ஆய்வகம் , ப்ரொஃபெஸர் கார்மென் பிர்ச்மியர் , சமிக்ஞை கடத்தல் ஆய்வகம் , மூலக்கூறு மருந்து , ப்ரொஃபெஸர் ஜன ஓநாய் ,

Study unlocks some muscle cell secrets

Study unlocks some muscle cell secrets
A muscle fiber consists of just one cell, but many nuclei. A team at the MDC led by Professor Carmen Birchmeier has now shown just how varied these nuclei are. The study, which has been published in
Nature Communications, can help us better understand muscle diseases such as Duchenne muscular dystrophy.
Usually, each cell has exactly one nucleus. But the cells of our skeletal muscles are different: These long, fibrous cells have a comparatively large cytoplasm that contains hundreds of nuclei. But up to now, we have known very little about the extent to which the nuclei of a single muscle fiber differ from each other in terms of their gene activity, and what effect this has on the function of the muscle. ....

Carmen Birchmeier , Minchul Kim , Vedran Franke , Altuna Akalin , Emily Henderson , Nature Communications , Max Delbrueck Center , Helmholtz Association , Berlin Institute Of Medical Systems Biology , Professor Carmen Birchmeier , Developmental Biology , Signal Transduction , Molecular Medicine , Omics Data Science Platform , Medical Systems Biology , Medical Systems , கார்மென் பிர்ச்மியர் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , பெர்லின் நிறுவனம் ஆஃப் மருத்துவ அமைப்புகள் உயிரியல் , ப்ரொஃபெஸர் கார்மென் பிர்ச்மியர் , வளர்ச்சி உயிரியல் , சமிக்ஞை கடத்தல் , மூலக்கூறு மருந்து , மருத்துவ அமைப்புகள் உயிரியல் , மருத்துவ அமைப்புகள் ,

Muscle cell secrets

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IMAGE: In this single muscle fiber, a multitude of nuclei can be clearly seen. The researchers used DAPI for staining, it stains the DNA in the nuclei blue.
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Credit: C. Birchmeier Lab, MDC
A muscle fiber consists of just one cell, but many nuclei. A team at the MDC led by Professor Carmen Birchmeier has now shown just how varied these nuclei are. The study, which has been published in
Nature Communications, can help us better understand muscle diseases such as Duchenne muscular dystrophy.
Usually, each cell has exactly one nucleus. But the cells of our skeletal muscles are different: These long, fibrous cells have a comparatively large cytoplasm that contains hundreds of nuclei. But up to now, we have known very little about the extent to which the nuclei of a single muscle fiber differ from each other in terms of their gene activity, and what effect this has on the function of the muscle. ....

Carmen Birchmeier , Minchul Kim , Vedran Franke , Altuna Akalin , Nature Communications , Max Delbrueck Center , Helmholtz Association , Berlin Institute Of Medical Systems Biology , Professor Simone Spuler Myology Lab , Professor Carmen Birchmeier , Developmental Biology , Signal Transduction , Molecular Medicine , Omics Data Science Platform , Medical Systems Biology , Professor Simone Spuler , Myology Lab , கார்மென் பிர்ச்மியர் , இயற்கை தகவல்தொடர்புகள் , பெர்லின் நிறுவனம் ஆஃப் மருத்துவ அமைப்புகள் உயிரியல் , ப்ரொஃபெஸர் கார்மென் பிர்ச்மியர் , வளர்ச்சி உயிரியல் , சமிக்ஞை கடத்தல் , மூலக்கூறு மருந்து , மருத்துவ அமைப்புகள் உயிரியல் , மியொலோகி ஆய்வகம் ,

Study reveals surprising variability of muscle cells

Study reveals surprising variability of muscle cells
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

Carmen Birchmeier , Minchul Kim , Vedran Franke , Altuna Akalin , Nature Communications , Max Delbrueck Center , Helmholtz Association , C Birchmeier Lab , Berlin Institute Of Medical Systems Biology , Professor Simone Spuler Myology Lab , Professor Carmen Birchmeier , Signal Transduction , Molecular Medicine , Omics Data Science Platform , Medical Systems Biology , Professor Simone Spuler , Myology Lab , கார்மென் பிர்ச்மியர் , இயற்கை தகவல்தொடர்புகள் , பெர்லின் நிறுவனம் ஆஃப் மருத்துவ அமைப்புகள் உயிரியல் , ப்ரொஃபெஸர் கார்மென் பிர்ச்மியர் , சமிக்ஞை கடத்தல் , மூலக்கூறு மருந்து , மருத்துவ அமைப்புகள் உயிரியல் , மியொலோகி ஆய்வகம் ,