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Proteins play crucial role in muscle growth

Proteins play crucial role in muscle growth
When a muscle grows, because its owner is still growing too or has started exercising regularly, some of the stem cells in this muscle develop into new muscle cells.
The same thing happens when an injured muscle starts to heal. At the same time, however, the muscle stem cells must produce further stem cells - i.e., renew themselves - as their supply would otherwise be depleted very quickly. This requires that the cells involved in muscle growth communicate with each other.
Muscle growth is regulated by the Notch signaling pathway
Two years ago, a team of researchers led by Professor Carmen Birchmeier, head of the Developmental Biology/Signal Transduction Lab at the Berlin-based Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), showed that the development of stem cells into muscle cells is regulated with the help of two proteins, Hes1 and MyoD, which are produced in the progenitor cells in an ....

Max Delbr , Jana Wolf , Carmen Birchmeier , Ines Lahmann , Yao Zhang , Katharina Baum , Emily Henderson , Nature Communications , Developmental Biology Signal Transduction Lab , Helmholtz Association , Professor Carmen Birchmeier , Signal Transduction Lab , Berlin Based Max Delbr , Molecular Medicine , Professor Jana Wolf , Developmental Biology , Notch Signaling , Progenitor Cells , Signaling Pathway , Stem Cells , ஜன ஓநாய் , கார்மென் பிர்ச்மியர் , யாவ் ஜாங் , காதரின பாம் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் ,

The key to proper muscle growth

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IMAGE: Immunofluorescence analysis of a group of proliferating stem cells associated with a muscle fiber (grey). The stem cells produce Dll1 (red) and MyoD (green). Two of the cells produces MyoG.
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Credit: Birchmeier Lab, MDC
When a muscle grows, because its owner is still growing too or has started exercising regularly, some of the stem cells in this muscle develop into new muscle cells. The same thing happens when an injured muscle starts to heal. At the same time, however, the muscle stem cells must produce further stem cells - i.e., renew themselves - as their supply would otherwise be depleted very quickly. This requires that the cells involved in muscle growth communicate with each other. ....

Max Delbr , Jana Wolf , Carmen Birchmeier , Ines Lahmann , Yao Zhang , Katharina Baum , Nature Communications , Helmholtz Association , Developmental Biology Signal Transduction Lab , Professor Carmen Birchmeier , Signal Transduction Lab , Berlin Based Max Delbr , Molecular Medicine , Professor Jana Wolf , Medicine Health , Developmental Reproductive Biology , ஜன ஓநாய் , கார்மென் பிர்ச்மியர் , யாவ் ஜாங் , காதரின பாம் , இயற்கை தகவல்தொடர்புகள் , வளர்ச்சி உயிரியல் சமிக்ஞை கடத்தல் ஆய்வகம் , ப்ரொஃபெஸர் கார்மென் பிர்ச்மியர் , சமிக்ஞை கடத்தல் ஆய்வகம் , மூலக்கூறு மருந்து , ப்ரொஃபெஸர் ஜன ஓநாய் ,

Researchers investigate protein phosphatase to identify new treatments for cancer, other diseases

Researchers investigate protein phosphatase to identify new treatments for cancer, other diseases
The abundant presence of an enzyme known as low molecular weight protein tyrosine phosphatase (LMWPTP) in tumor cells has long been considered an indicator of cancer aggressiveness and metastatic potential. It is also known to perform important functions in cells under normal conditions, participating in both the proliferation process and the regulation of intracellular systems. Research continues on its role in cancer progression.
In Brazil, a group of researchers at the University of Campinas s In Vitro Bioassay and Signal Transduction Laboratory led by Professor Carmen Veríssima Ferreira-Halder are studying the possibility of inhibiting this protein phosphatase to create novel opportunities for monitoring and treatment of cancer and other diseases. ....

Erasmus Mc Moniek , Emanuella Maria Barreto Fonseca , Nunzio Bottini , Helon Guimar , Sousa Faria , Sheila Siqueira Andrade , Emily Henderson , University Of California San Diego , University Of Campinas In Vitro Bioassay , Molecular Life Sciences , Transduction Laboratory , University Of Campinas , Vice Rectorship For International Relations , Vitro Bioassay , Signal Transduction Laboratory , Professor Carmen Ver , Thematic Project , Professor Maikel Peppelenbosch , Erasmus University Medical Center , Alessandra Val , California San Diego , Executive Vice Rectorship , Stefano Piatto Clerici , Plateinnove Biotech , Moniek De Maat , Gwenny Fuhler ,