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IMAGE: Interneuron, stained green, with positive markings for trkB.DN, stained orange, and parvalbumina, stained blue. These results prove that trkB.DN-expressing inhibitory interneurons were successfully inserted by the viral vector.
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Credit: Nicolas Guyon
Researchers used genetic engineering tools to create a virus that can enter specific neurons and insert into the prefrontal cortex a new genetic code that induces the production of modified proteins. In tests with mice, the alteration of these proteins was sufficient to modify brain activity, indicating a potential biomarker for the diagnosis of psychiatric disorders such as schizophrenia and autism.
Sometimes referred to as the executive brain , the prefrontal cortex is the region that governs higher-level cognitive functions and decision making. Studies of tissue from this brain region in patients with schizophrenia have detected alterations in two proteins: BDNF (brain-derived ....

Minas Gerais , Marie Carl , Leonardo Rakauskas Zacharias , Nicolas Gustavo Guyon , Paulo Ribeir , Cleiton Lopes Aguiar , Epilepsy Research Laboratory , Karolinska Institute , Institute Of Biological Sciences , Sweden Karolinska Institute , University Of Minas Gerais , Preto Medical School , Paulo Research Foundation , Pan American Health Organization , Federal University , Higher Education Personel , Biological Sciences , Research Laboratory , Medicine Health , Social Behavioral Science , Coping Phobias , Gene Therapy , மினாஸ் கெரைச் , மேரி கார்ல் , கால் கை வலிப்பு ஆராய்ச்சி ஆய்வகம் , நிறுவனம் ஆஃப் உயிரியல் அறிவியல் ,