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Scientists use genetic engineering to explore mechanisms involved in psychiatric disorders


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IMAGE: Interneuron, stained green, with positive markings for trkB.DN, stained orange, and parvalbumina, stained blue. These results prove that trkB.DN-expressing inhibitory interneurons were successfully inserted by the viral vector.
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Credit: Nicolas Guyon
Researchers used genetic engineering tools to create a virus that can enter specific neurons and insert into the prefrontal cortex a new genetic code that induces the production of modified proteins. In tests with mice, the alteration of these proteins was sufficient to modify brain activity, indicating a potential biomarker for the diagnosis of psychiatric disorders such as schizophrenia and autism.
Sometimes referred to as the executive brain , the prefrontal cortex is the region that governs higher-level cognitive functions and decision making. Studies of tissue from this brain region in patients with schizophrenia have detected alterations in two proteins: BDNF (brain-derived ....

Minas Gerais , Marie Carl , Leonardo Rakauskas Zacharias , Nicolas Gustavo Guyon , Paulo Ribeir , Cleiton Lopes Aguiar , Epilepsy Research Laboratory , Karolinska Institute , Institute Of Biological Sciences , Sweden Karolinska Institute , University Of Minas Gerais , Preto Medical School , Paulo Research Foundation , Pan American Health Organization , Federal University , Higher Education Personel , Biological Sciences , Research Laboratory , Medicine Health , Social Behavioral Science , Coping Phobias , Gene Therapy , மினாஸ் கெரைச் , மேரி கார்ல் , கால் கை வலிப்பு ஆராய்ச்சி ஆய்வகம் , நிறுவனம் ஆஃப் உயிரியல் அறிவியல் ,

Reports of Malpractices: Recruitment at RU halted


This paper has obtained copies of all the orders.
The allegations against the VC include nepotism and illegal occupation of a duplex of the university.
The UGC probe found that the vice-chancellor and other RU officials relaxed the recruitment rules to appoint the VC s daughter and son-in-law as teachers.
Meanwhile, the government in a separate order on December 10 postponed all kinds of appointments to RU until further notice.
The order, copy of which has been obtained by this paper, says all appointment processes will remain suspended until further notice due to administrative reasons .
Top education ministry officials said they issued the order as the government came to know about some negative news regarding the malpractices in the recruitment process . ....

Rajshahi University , M Abdus Sobhan , Mohibul Hassan Chowdhoury , Choudhurym Zakaria , Teacher Society Against Corruption , University Grants Commission , Institute Of Biological Sciences , Corruption Commission , Office On , Higher Education Division , Daily Star , Biological Sciences , Society Against , Anti Corruption Commission , Prime Minister , ராஜ்ஷாஹி பல்கலைக்கழகம் , மீ அப்துஸ் சோபன் , ஆசிரியர் சமூகம் எதிராக ஊழல் , பல்கலைக்கழகம் மானியங்கள் தரகு , நிறுவனம் ஆஃப் உயிரியல் அறிவியல் , ஊழல் தரகு , அலுவலகம் ஆன் , அதிக கல்வி பிரிவு , தினசரி நட்சத்திரம் , உயிரியல் அறிவியல் , சமூகம் எதிராக ,