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'Junk DNA' plays a key role in regulating circadian clocks


‘Junk DNA’ plays a key role in regulating circadian clocks
January 7, 2021USC
Study suggests the impact of non-coding microRNAs on circadian rhythms is tissue specific and may reveal new insights into disease processes.
If you’ve ever had a bad case of jet lag, you know how a disruption to your body’s circadian rhythm makes it difficult to function. Molecular circadian “clocks” exist in cells throughout the body, governing more than just sleep and wake cycles they are crucial to many aspects of human health. For more than a decade, researchers have been trying to figure out what makes them tick, in search of new insights into diseases like Alzheimer’s, cancer and diabetes. ....

San Diego , United States , Caitlyn Miller , Steve Kay , Lili Zhou , Proceedings Of The National Academy Sciences , Keck School Of Medicine , Genomics Institute Of The Novartis Research Foundation , Keck School Department Of Neurology , National Academy , Provost Professor , Keck School , Genomics Institute , Novartis Research Foundation , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , கைட்லின் மில்லர் , ஸ்டீவ் காய் , லில்லி ஜூ , கேக்க் பள்ளி ஆஃப் மருந்து , மரபியல் நிறுவனம் ஆஃப் தி நோவர்த்திச் ஆராய்ச்சி அடித்தளம் , கேக்க் பள்ளி துறை ஆஃப் நரம்பியல் , தேசிய கலைக்கழகம் , புரோஸ்ட் ப்ரொஃபெஸர் , கேக்க் பள்ளி , மரபியல் நிறுவனம் ,

'Junk DNA' plays a key role in regulating our circadian clocks


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‘Junk DNA’ plays a key role in regulating our circadian clocks
If you’ve ever had a bad case of jet lag, you know how a disruption to your body’s circadian rhythm makes it difficult to function. Molecular circadian “clocks” exist in cells throughout the body, governing more than just sleep and wake cycles they are crucial to many aspects of human health. For more than a decade, researchers have been trying to figure out what makes them tick, in search of new insights into diseases like Alzheimer’s, cancer and diabetes.
Until now, that research has focused on what is known as clock genes, which encode proteins that drive oscillating cycles of gene expression affecting physiology and behavior. But research just published in the Proceedings of the National Academy of Sciences reveals the discovery of a new cog in the circadian clock a genome-wide regulatory layer made up of small chains of non-coding nucleotides known as micro RNAS (miRNAs). ....

San Diego , United States , Caitlyn Miller , Angelica Romero , Lorenj Miraglia , Steve Kay , Lili Zhou , National Institute Of Diabetes , Proceedings Of The National Academy Sciences , Keck School Of Medicine , Genomics Institute Of The Novartis Research Foundation , Keck School Department Of Neurology , National Academy , Provost Professor , Keck School , Genomics Institute , Novartis Research Foundation , Satchidananda Panda , Salk Institute , National Institute , Kidney Diseases Grant , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , கைட்லின் மில்லர் , ஏஞ்சலிகா ரொமெரோ , ஸ்டீவ் காய் ,