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New eye surface reconstruction method using mussel adhesive protein


New eye surface reconstruction method using mussel adhesive protein
The eye is the first sensory organ that recognizes the presence or shape of an object. The conjunctiva is a thin mucous membrane that covers the front half of the eyeball. It protects the eye by secreting mucus and tears for lubrication, and prevents microorganisms from entering. However, since it is exposed to the air, it is susceptible to damages by microorganisms, bacteria, or dust. In fact, if fibrovascular tissues are left to propagate on its surface, they can lead to diseases like pterygium, which can cause visual deterioration. To treat such conditions, an operation to remove and regenerate the damaged conjunctiva is performed. Recently, a Korean research team has developed a new method for performing sutureless amniotic membrane transplantation using the mussel adhesive protein. ....

Kyongsang Namdo , South Korea , Hyung Joon Cha , Emily Henderson , Korea Health Industry Development Institute , Ministry Of Health , Korea Health Technology , Nano New Materials Core Technology Development Program , Donga University College Of Medicine , Nature Gluetech Co Ltd , Ministry Of Oceans , Ministry Of Science , Seong Woo Maeng , Tae Yoon Park , Professor Woo Chan Park , Donga University College , Eye Hospital , Konyang University School , Advanced Healthcare Materials , Korea Health Technology Rd Project , Marine Biotechnology Program , Korea Institute , Marine Science , Technology Promotion , தெற்கு கொரியா , யுங் ஜூன் சிஎச்ஏ ,

Metabolically engineered stem cell–derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis


Abstract
Despite the remarkable advances in therapeutics for rheumatoid arthritis (RA), a large number of patients still lack effective countermeasures. Recently, the reprogramming of macrophages to an immunoregulatory phenotype has emerged as a promising therapeutic strategy for RA. Here, we report metabolically engineered exosomes that have been surface-modified for the targeted reprogramming of macrophages. Qualified exosomes were readily harvested from metabolically engineered stem cells by tangential flow filtration at a high yield while maintaining their innate immunomodulatory components. When systemically administered into mice with collagen-induced arthritis, these exosomes effectively accumulated in the inflamed joints, inducing a cascade of anti-inflammatory events via macrophage phenotype regulation. The level of therapeutic efficacy obtained with bare exosomes was achievable with the engineered exosomes of 10 times less dose. On the basis of the boosted nature to ....

United States , Soult Ukpyolsi , South Korea , Castillay Leóp , Republic Of Korea , Takara Bio , Exosomes Exos , Leica Biosystems , Bioanalyzer Santa Clara , Analyte Elisarray , Exos Msc , Korea Basic Science Institute National Research Facilities , Younglin Co , Science Research Programs , Korea Basic Science Institute , Agilent Technologies , National Research Foundation , Sungkyunkwan University , Central Lab Animal Inc , Ministry Of Health Welfare , Exostemtech Inc , Aldrich Co , Ministry Of Education , Equipment Center , Hyclone Laboratories Inc , Spectrum Laboratories Inc ,