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Study uncovers novel mechanism in rare mutation associated with Alzheimer s
A novel mechanism has been identified that might explain why a rare mutation is associated with familial Alzheimer s disease in a new study by investigators at the University of Chicago. The paper, published on April 2 in the
Journal of Experimental Medicine, characterizes a mutation located in a genetic region that was not previously thought be pathogenic, upending assumptions about what kinds of mutations can be associated with Alzheimer s Disease.
Alzheimer s, a neurodegenerative disease that currently affects more than 6 million Americans, has been characterized by the accumulation of Aβ peptide into plaques in the spaces between neurons in the brain. These Aβ peptide are generated when a larger precursor protein, APP, is cleaved into smaller fragments as APP transits through different cellular compartments. ....

United States , Sangram Sisodia , Xulun Zhang , Emily Henderson , University Of Chicago , Experimental Medicine , Senior Author , Thomas Reynolds , Family Professor , Research Professional , Alzheimer 39s Disease , Neurodegenerative Disease , ஒன்றுபட்டது மாநிலங்களில் , சங்கிராம் சிசோடியா , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் சிகாகோ , சோதனை மருந்து , மூத்தவர் நூலாசிரியர் , தாமஸ் ரெனால்ட்ஸ் , குடும்பம் ப்ரொஃபெஸர் , ஆராய்ச்சி ப்ரொஃபெஶநல் ,