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Study reveals the implication of lysosomes in the spread of Parkinson's disease


Study reveals the implication of lysosomes in the spread of Parkinson’s disease
Over the last few decades, neurodegenerative diseases became one of the top 10 global causes of death. Researchers worldwide are making a strong effort to understand neurodegenerative diseases pathogenesis, which is essential to develop efficient treatments against these incurable diseases. However, our knowledge about the basic molecular mechanisms underlying the pathogenesis of neurodegenerative diseases is still lacking. A team of researchers found out the implication of lysosomes in the spread of Parkinson s disease.
The accumulation of misfolded protein aggregates in affected brain regions is a common hallmark shared by several neurodegenerative diseases (NDs). Mounting evidence in cellular and in animal models highlights the capability of different misfolded proteins to be transmitted and to induce the aggregation of their endogenous counterparts, this process is called seeding . In P ....

Institut Pasteur , Chiara Zurzolo , Emily Henderson , French National Centre For Scientific Research , French National Centre , Scientific Research , Membrane Traffic , Pathogenesis Unit , நிறுவனம் பாஸ்டர் , எமிலி ஹென்டர்சன் , பிரஞ்சு தேசிய மையம் க்கு அறிவியல் ஆராய்ச்சி , பிரஞ்சு தேசிய மையம் , அறிவியல் ஆராய்ச்சி , சவ்வு போக்குவரத்து ,