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How UT Research Led to the Development of the COVID-19 Vaccine in Record-Breaking Time

Jason McLellan in his lab on January 18, 2021.
Credit: Matt Wright-Steel
On January 6, 2020, Jason McLellan and his wife, Jinelle, were in Park City, Utah, for their family’s first-ever snowboarding vacation. It was a chance for the couple and their two young kids to relax after the holidays and before the spring semester kicked off at UT, when McLellan would begin his second year as an associate professor in molecular biosciences. 
McLellan’s new snowboarding boots were pinching him, so he stopped at a shop to get them heat-molded to his feet. While he waited, McLellan saw Barney Graham’s name flash across his phone. The pair had first met in 2008 at the National Institutes of Health (NIH), where Graham is deputy director of the National Institute of Allergy and Infectious Diseases’ Vaccine Research Center, and McLellan was conducting his postdoctoral research in structure-based vaccine design after receiving his PhD from Johns Hopkins. ....

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Remdesivir 'trick' could lead to better antiviral treatments

Remdesivir is the only treatment of its kind currently approved in the US for the coronavirus.
The findings could lead to more effective antiviral treatments.
Remdesivir targets a part of the coronavirus that allows it to make copies of itself and spread through the body. For the first time, scientists identified a critical mechanism that the drug uses and unearthed information that drug companies can use to develop new and improved antivirals to take advantage of the same trick.
The finding could also lead to more potent drugs, meaning a patient could take less of a dose, see fewer side effects, and experience faster relief, says Kenneth Johnson, professor of molecular biosciences at the University of Texas at Austin and coauthor of the paper in ....

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Scientists Discover How Remdesivir Works to Inhibit Coronavirus

Date Time
Scientists Discover How Remdesivir Works to Inhibit Coronavirus
More effective antiviral treatments could be on the way after research from The University of Texas at Austin sheds new light on the COVID-19 antiviral drug remdesivir, the only treatment of its kind currently approved in the U.S. for the coronavirus.
Remdesivir targets a part of the coronavirus that allows it to make copies of itself and spread through the body. For the first time, scientists identified a critical mechanism that the drug uses and unearthed information that drug companies can use to develop new and improved antivirals to take advantage of the same trick. ....

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