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Scientists identify protein that could serve as a therapeutic target in lung cancer


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Scientists at VCU Massey Cancer Center have identified a protein that operates in tandem with a specific genetic mutation to spur lung cancer growth and could serve as a therapeutic target to treat the disease.
Mutations in the p53 gene are found in more than half of all cancers, but it remains difficult to effectively target the gene with drugs even decades after its discovery. Though previous research has shown that p53 acts as a tumor suppressor and initiates cancer cell death in its natural state, a new study led by Sumitra Deb, Ph.D., suggests that gain-of-function (GOF) mutations a type of mutation where the changed gene has an added function turn p53 into an oncogene, causing cells to replicate uncontrollably and contribute to cancer development. ....

United States , Elizabeth Fry , Jolene Windle , Sumitra Deb , Brad Windle , Andrew Yeudall , Kazushi Inoue , Swati Deb , Shilpa Singh , Catherine Vaughan , Raghavendra Pillappa , Mark Subler , Steven Grossman , Nature Communications , School Of Medicine , Norris Comprehensive Cancer Center , Georgia Cancer Center At Augusta University , Department Of Biochemistry , Massey Cancer Center , Wake Forest University School Of Medicine , Cancer Center , Cancer Biology , Molecular Biology , Comprehensive Cancer Center , Georgia Cancer Center , Augusta University ,

Georgia Cancer Center research looks at plant-derived compound


Dr. Ahmed Chadli literally went back to his roots to find a promising therapy that could potentially fight breast cancer and help harness the immune system to do it.
Chadli, an associate professor of medicine at Georgia Cancer Center at Augusta University, recently got a $1.8 million grant from the National Cancer Institute to look at a compound that is derived from a fungus found on the roots of some plants in his native Morocco.
The EnnA protein appears to work by inhibiting a prominent protein involved in cancer cell survival called heat shock protein 90 or hsp90. When its role in cancer was first discovered in the 1990s, it caused a lot of excitement because of its interaction with many cancer-promoting functions. ....

United States , Atlas Mountains , Morocco General , Tom Corwin Augusta , Ahmed Chadli , National Cancer Institute , Augusta University , Georgia Cancer Center At Augusta University , Georgia Cancer Center , South America , ஒன்றுபட்டது மாநிலங்களில் , அட்லஸ் மலைகள் , மொராக்கோ ஜநரல் , டோம் கார்வின் அகஸ்டா , தேசிய புற்றுநோய் நிறுவனம் , அகஸ்டா பல்கலைக்கழகம் , ஜார்ஜியா புற்றுநோய் மையம் இல் அகஸ்டா பல்கலைக்கழகம் , ஜார்ஜியா புற்றுநோய் மையம் , தெற்கு அமெரிக்கா ,