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Researchers identify new molecular mechanisms in chronic skin inflammation

Researchers identify new molecular mechanisms in chronic skin inflammation
Frequently occurring chronic skin inflammation like in atopic dermatitis (AD or neurodermatitis) and psoriasis have different causes such as genetic predisposition, stress or allergens.
These frequently occurring skin diseases are mostly attributed by biomedical scientists to a disturbed immune system, although the noticeable thickening and flaking of the epidermis, which is the outermost layer of skin, also indicates a disruption of the epithelial cells.
A team of researchers from the University Clinic for Dermatology and the Clinical Institute for Laboratory Medicine at MedUni Vienna has now been able to identify new molecular mechanisms as causes that could provide suitable starting points for new therapies. ....

Erwin Wagner , Emily Henderson , University Clinic For Dermatology , University Clinic , Clinical Institute , Laboratory Medicine , Meduni Vienna , Atopic Dermatitis , Immune System , அர்‌விந் வாக்னர் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் சிகிச்சையகம் க்கு தோல் நோய் , பல்கலைக்கழகம் சிகிச்சையகம் , மருத்துவ நிறுவனம் , ஆய்வகம் மருந்து , தோல் நோய் , நோய் எதிர்ப்பு சக்தி அமைப்பு , மன அழுத்தம் ,

Genetic variation associated with COVID-19 outcome

Genetic variation associated with COVID-19 outcome
The severity of outcome from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is widely varied, with most individuals remaining asymptomatic while others experience severe life-threatening pneumonia and multi-organ failure. Host genetics play a role in disease progression and prognosis. A paper recently uploaded to the preprint server
et al. (1
st March 2021) identifies several alleles associated with the gene natriuretic peptide receptor C (NPR3) that may impact disease severity.
How was the study performed?
The group worked with 4,488 high-risk COVID-19 outpatients being over 40 years of age and having at least one other comorbidity such as diabetes or obesity. The group was split into two equal sizes, one of which received a placebo, while the other received 0.5 mg colchicine, an anti-inflammatory, daily for a month. The patients were evaluated for disease symptoms 15 and 30 days into ....

Michael Greenwood , Image Credit , Chromosome 9 , Corona Virus , Coronavirus Disease Covid 19 , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , மைக்கேல் கிரீன்வுட் , படம் கடன் , கொரோனா வைரஸ் , நீரிழிவு நோய் , உடல் பருமன் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Genomic surveillance can help identify how SARS-CoV-2 spreads in care homes

Genomic surveillance can help identify how SARS-CoV-2 spreads in care homes
Care homes are at high risk of experiencing outbreaks of COVID-19, the disease caused by SARS-CoV-2. Older people and those affected by heart disease, respiratory disease and type 2 diabetes - all of which increase with age - are at greatest risk of severe disease and even death, making the care home population especially vulnerable.
Care homes are known to be high-risk settings for infectious diseases, owing to a combination of the underlying vulnerability of residents who are often frail and elderly, the shared living environment with multiple communal spaces, and the high number of contacts between residents, staff and visitors in an enclosed space. ....

United Kingdom , Gerry Tonkin Hill , Emily Henderson , University Of Cambridge , Public Health England , Genomics United Kingdom Consortium , Laboratory In Cambridge , Cambridge University Hospitals , Wellcome Sanger Institute , Honorary Consultant , Honorary Senior Visiting Fellow , William Hamilton , Wellcome Sanger , Health Care , Heart Disease , Infection Control , Infectious Diseases , Respiratory Disease , Sars Cov 2 , Type 2 Diabetes , ஒன்றுபட்டது கிஂக்டம் , ஜெர்ரி டான்கின் மலை , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் , பொது ஆரோக்கியம் இங்கிலாந்து , மரபியல் ஒன்றுபட்டது கிஂக்டம் கூட்டமைப்பு ,

Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis

Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis
Scientists at the Francis Crick Institute and UCL have identified the trigger of a key cellular change in amyotrophic lateral sclerosis (ALS), a type of motor neurons disease. The findings could help develop new treatments for many neurological diseases with the same change, including Parkinson s and Alzheimer s.
When the nervous system is injured, diseased or infected, star-shaped cells, called astrocytes, undergo reactive changes in their behavior. Whilst some of these reactive astrocytes become protective, others become harmful and damage surrounding motor neurons.
Reactive astrocytes are observed in various neurodegenerative diseases including ALS, but there is a lack of understanding about what causes astrocytes to undergo this change. ....

Oliver Ziff , Rickie Patani , Emily Henderson , National Hospital For Neurology , Queen Square Institute Of Neurology , Group Leader , Nucleic Acids Research , Francis Crick Institute , Senior Study Author , Queen Square Institute , Consultant Neurologist , National Hospital , Square Institute , Motor Neurone Disease , Amyotrophic Lateral Sclerosis , Genetic Information , Motor Neurons , Nervous System , Neurodegenerative Diseases , Stem Cells , ஆலிவர் ஸிஃப் , ரிக்கி படானி , எமிலி ஹென்டர்சன் , தேசிய மருத்துவமனை க்கு நரம்பியல் , ராணி சதுரம் நிறுவனம் ஆஃப் நரம்பியல் , குழு தலைவர் ,

Evolutionary forces account for gender imbalance in the occurrence of autism, other health conditions

Evolutionary forces drive a glaring gender imbalance in the occurrence of many health conditions, including autism, a team of genetics researchers has concluded. ....

Rama Singh , Karun Singh , Emily Henderson , University Of Toronto , Shiva Singh , Associate Professor , Cervical Cancer , Mental Health , Ovarian Cancer , ராமா சிங் , கருண் சிங் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , சிவா சிங் , இணை ப்ரொஃபெஸர் , மன இறுக்கம் , சிஇஆர்விஐசிஏஎல் புற்றுநோய் , மன ஆரோக்கியம் , ஓவாயரியந் புற்றுநோய் ,