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MorphoSys AG: MorphoSys and Incyte Announce First Patient Dosed in Phase 3 frontMIND Study Evaluating Tafasitamab Combination as a First-line Treatment for Diffuse Large B-Cell Lymphoma


MorphoSys AG: MorphoSys and Incyte Announce First Patient Dosed in Phase 3 frontMIND Study Evaluating Tafasitamab Combination as a First-line Treatment for Diffuse Large B-Cell Lymphoma
The
frontMIND (NCT04824092) trial is a randomized, double-blind, placebo-controlled, global Phase 3 clinical study in previously untreated high-intermediate and high-risk DLBCL patients that is conducted in partnership with the German Lymphoma Association (GLA), the Italian Lymphoma study group and the US Oncology Network.
The study aims to enroll approximately 880 DLBCL patients to receive either tafasitamab plus lenalidomide in addition to rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) or R-CHOP alone. The primary endpoint is investigator-assessed progression-free survival, according to Lugano 2014 criteria, and key secondary endpoints include event-free survival by investigator, overall survival, metabolic complete response rate by a Blinded Independen ....

United States , Italy General , Julia Neugebauer , Peter Langmuir , Mike Akimov , Myles Clouston , Jeanette Bressi , Thomas Biegi , Catalina Loveman , Christine Chiou , Jenifer Antonacci , Practice Research Clinical Haematology , Us Communications , Head Of Global Drug Development , Janssen Biotech Inc , Xencor Inc , Janssen Research Development , Morphosys Us Inc , American Society Of Hematology , Public Affairs , Decision Resources Group , World Health Organization Subtypes , Drug Administration , Group Vice , German Lymphoma Association , Exchange Commission ,