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Yale targets COVID-19 with innovative computational design methods

By Jim Shelton
February 24, 2021
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Yale scientists have developed a new class of antiviral agents that shows promise for creating COVID-19 therapeutics exhibiting particular effectiveness when used in tandem with the drug remdesivir, another antiviral medication approved for use against the virus.
The new compounds are the first potent, drug-like, non-covalent, and non-peptidic inhibitors of the main protease, or enzyme, in SARS-CoV-2 that is crucial for processing essential viral proteins. A study demonstrating the compounds appears in the journal ACS Central Science.
The work is the latest collaboration of Yale researchers William Jorgensen and Karen Anderson, senior co-authors of the study, who use high-level computation and structural biology methods to design compounds that target viral proteins. ....

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Flat Rock Life: Playhouse launches 'Rock Solid' campaign to combat Covid damage

Dubbed Rock Solid, the campaign aims to preserve the legacy of the Playhouse, ignite the passion for theatre in the community and revitalize the arts in Henderson County and beyond. The campaign kicks off with a generous gift from David Leiman, matching donors’ contributions dollar for dollar up to $118,000.
After beginning their 2020 season in the strongest financial position in over a decade, the Playhouse was forced to go dark in mid-March because of the worldwide pandemic, government restrictions and industry health standards placed on large performing arts venues. The State Theatre of North Carolina, which relies heavily on ticket revenue, furloughed two-thirds of its staff, and for the first time in its history, was unable to invite summer apprentices and interns to the Rock a critical component of their core value to educate/mentor future professional artists going back 70+ years. Though unable to offer their intended 2020 season, the Playhouse hosted two virtu ....

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