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Researchers make 'bombshell' discovery of an entirely new kind of biomolecule


Date Time
Researchers make ‘bombshell’ discovery of an entirely new kind of biomolecule
A newfound biomolecule, consisting of RNA modified by sugars, could be present in all forms of life and might contribute to autoimmune disease.
By Holly Alyssa MacCormick
Stanford researchers have discovered a new kind of biomolecule that could play a significant role in the biology of all living things.
The novel biomolecule, dubbed glycoRNA, is a small ribbon of ribonucleic acid (RNA) with sugar molecules, called glycans, dangling from it. Up until now, the only kinds of similarly sugar-decorated biomolecules known to science were fats (lipids) and proteins. These glycolipids and glycoproteins appear ubiquitously in and on animal, plant and microbial cells, contributing to a wide range of processes essential for life. ....

United States , Stacy Malaker , Benson George , Kayvon Pedram , Holly Alyssa Maccormick , Alex Johnson , Karim Majzoub , Jan Carette , Stanford Bio , Howard Chang , Ryan Flynn , Carolyn Bertozzi , Stanford School Of Humanities , National Cancer Institute , National Science Foundation , Department Of Stem Cell , Damon Runyon Cancer Research , Dk Ludwig Professor Of Cancer Research , Cancer Research Of The United States , Maternal Child Health Research Institute , National Institute , Stanford Wu Tsai Neurosciences Institute , Yale University , Stanford Chemistry Biology Interface Predoctoral Training Program , National Institutes Of Health , Medicine For Human Health ,

Gift boosts efforts to understand and combat rare cancers


Gift boosts efforts to understand and combat rare cancers
Apr 9 2021
Curing cancer has been the dream of countless doctors and researchers over the decades. Yet some types of cancer, whether because they affect relatively few people or lack influential advocates, receive less attention and funding than others.
Cells from a rare cancer known as blastic plasmacytoid dendritic cell neoplasm, shown in purple and blue, appear among red blood cells. Image: Clin Med Insights Case Rep 2013. doi: 10.4137/CCRep.S12608, CC-BY-NC 3.0
A recent gift to Harvard Medical School is boosting efforts to understand and combat these understudied malignancies.
Established at HMS in 2019 by the Switzerland-based Bertarelli Foundation, the Bertarelli Rare Cancers Fund provides $15 million in support of research projects and community building around rare cancers. ....

United States , Dana Farber Cancer Institute , Dona Bertarelli , Kimberly Stegmaier , Austinl Vickery Jr , Stephen Elledge , Nabeel Bardeesy , Georgeq Daley , Fred Harlow , Vamsi Mootha , John Hanna , William Kaelin , John Iafrate , Miguel Rivera , National Cancer Institute , Harvard Medical School , Bertarelli Rare Cancers Fund , Bertarelli Foundation , Dk Ludwig Professor Of Cancer Research , Bertarelli Program In Translational Neuroscience , Blavatnik Institute , Clin Med Insights Case Rep , Switzerland Based Bertarelli Foundation , National Cancer , Cancer Research , Sidney Farber Professor ,