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Clinical trials start for USask's COVID-19 vaccine candidate


Published Wednesday, February 10, 2021 10:33PM EST
HALIFAX - Clinical trials have begun for another Canadian-made COVID-19 vaccine candidate, with three people receiving an initial dose on Wednesday.
The Canadian Center for Vaccinology says the first of 108 healthy adult volunteers received injections in Halifax. The placebo-controlled study will administer two doses to each volunteer, 28 days apart.
“It s a product of Canadian science, so it bodes well for the ability to make vaccines here. We all want to have vaccine manufacturing capacity in Canada,” said Dr. Joanne Langley, a vaccine researcher with the centre.
She said that the pace of testing is careful, as different age groups, from younger to older, receive varying doses in a process that will unfold over the next two months. ....

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Clinical trials begin for University of Saskatchewan's COVID-19 vaccine candidate


Kayle Neis/The Canadian Press
Clinical trials have begun for another Canadian-made COVID-19 vaccine candidate, with three people receiving an initial dose on Wednesday.
The Canadian Center for Vaccinology says the first of 108 healthy adult volunteers received injections in Halifax. The placebo-controlled study will administer two doses to each volunteer, 28 days apart.
“It’s a product of Canadian science, so it bodes well for the ability to make vaccines here. We all want to have vaccine manufacturing capacity in Canada,” said Dr. Joanne Langley, a vaccine researcher with the centre.
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She said that the pace of testing is careful, as different age groups, from younger to older, receive varying doses in a process that will unfold over the next two months. ....

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USask's VIDO begins COVID-19 vaccine clinical trials at CCfV


The trial was designed as a combined Phase 1/Phase 2 study. Phase 1 will vaccinate 108 healthy volunteers in a placebo-controlled study at the Canadian Center for Vaccinology (CCfV) in Halifax. Two doses will be administered to each volunteer 28 days apart.
“The goal of this trial is to help demonstrate vaccine safety in people,” said CCfV principal investigator Dr. Joanne Langley. “As part of this, we will monitor the health of the volunteers for a year after their vaccination.”
VIDO has worked on infectious disease vaccine projects with CCfV, the most recognized site in the country for vaccine clinical trials, for more than a decade. ....

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VIDO's COVID-19 vaccine receives Health Canada clinical trial approval


Subunit-based vaccines are a proven technology that has been used in many commercially available vaccines including for hepatitis, diphtheria, and whooping cough with an excellent safety profile. These well-established vaccines are relatively stable and have not required ultra cold storage temperatures.
The authorization from Health Canada enables the Canadian Center for Vaccinology (CCfV) in Halifax to begin recruiting volunteers for the first Phase 1 clinical trial. CCfV anticipates that the volunteers will be vaccinated in January.
“This is the first university-based COVID-19 vaccine to begin Phase 1 testing at CCfV. The purpose of this trial is to demonstrate the safety of the vaccine in humans,” said CCfV Director Dr. Scott Halperin. ....

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