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Research may lead to a significant breakthrough in the battle against deadly brain tumors


Research may lead to a significant breakthrough in the battle against deadly brain tumors
Groundbreaking research from Tel Aviv University may lead to a significant breakthrough in the battle against deadly brain cancer. To begin with, the researchers identified a failure in the brain s immune system, leading to the amplification of cell division and spread of Glioblastoma cancer cells. The failure results partially from the secretion of a protein called P-Selectin (SELP), which, when bound to its receptor on the brain immune cells, alters their function so that instead of inhibiting the spread of cancer cells, they do the opposite, enabling them to proliferate and penetrate brain tissues. ....

United States , Eilam Yeini , Ronit Satchi Fainaro , Asaf Madi , Emily Henderson , Johns Hopkins University , Israel Cancer Research Fund , Nature Communications , Lieber Institute , Head Of The Cancer Research , Israel Science Foundation , Nanomedicine Laboratory , Israel Cancer Association , Morris Kahn Foundation , Cancer Biology Research Center , Tel Aviv Sourasky Medical Center Ichilov , Kadar Family Awards For Outstanding Research , Tel Aviv University Sackler Faculty Of Medicine , European Research Council , Tel Aviv University , Cancer Research , Sackler Faculty , Tel Aviv Sourasky Medical Center , Kadar Family Awards , Outstanding Research , Immune System ,

Activating the brain's immune system against cancer prevents it from spreading


Credit: Tel Aviv University
Groundbreaking research from Tel Aviv University may lead to a significant breakthrough in the battle against deadly brain cancer. To begin with, the researchers identified a failure in the brain s immune system, leading to the amplification of cell division and spread of Glioblastoma cancer cells. The failure results partially from the secretion of a protein called P-Selectin (SELP), which, when bound to its receptor on the brain immune cells, alters their function so that instead of inhibiting the spread of cancer cells, they do the opposite, enabling them to proliferate and penetrate brain tissues.
At the next stage of the study, the researchers were able to inhibit the secretion of the SELP protein, thereby neutralizing the failure in the immune system, restoring its normal activity, and blocking the spread of this incurable cancer. The international research team was led by Prof. Ronit Satchi-Fainaro, Director of the Cancer Biology Research ....

United States , Eilam Yeini , Ronit Satchi Fainaro , Asaf Madi , Johns Hopkins University , Israel Cancer Research Fund , Nature Communications , Head Of The Cancer Research , Israel Science Foundation , Lieber Institute , Israel Cancer Association , Morris Kahn Foundation , Cancer Biology Research Center , Kadar Family Awards For Outstanding Research , Tel Aviv Sourasky Medical Center Ichilov , European Research Council , Tel Aviv University , Cancer Research , Nanomedicine Laboratory , Sackler Faculty , Tel Aviv Sourasky Medical Center , Kadar Family Awards , Outstanding Research , Cell Biology , Molecular Biology , Medicine Health ,