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Antibody Mediated Prevention (AMP) trials data published by the i New England Journal of Medicine /i

Antibody Mediated Prevention (AMP) trials data published by the
New England Journal of Medicine
Most advanced clinical trials testing broadly neutralizing antibody against HIV demonstrate efficacy against sensitive strains
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SEATTLE - (EMBARGOED UNTIL MARCH 17, 2021, AT 5 P.M. ET) - The proof-of-concept AMP studies demonstrated that a broadly neutralizing antibody (bnAb) called VRC01 was effective at preventing the acquisition of HIV strains to the 30% of strains that were sensitive to the bnAb. This finding was seen both in Sub-Saharan Africa and the U.S. and South America. VRCO1 did not prevent the acquisition of HIV to strains that were resistant to the bNAb. As the resistant strains constituted nearly 70% of the circulating strains in these regions, there was no difference noted between the VRC01 arms and placebo arm in terms of overall prevention of HIV acquisition. The sensitivity to bNAbs was ass ....

United States , South Africa , Sandy Van , Fred Hutch , Myron Cohen , Eric Miller , Larry Corey , National Institute Of Allergy , Us National Institutes Of Health , Prevention Trials Network , Us National Institute Of Allergy , Leadership Operations Center , Women Health Initiative , University Of North Carolina At Chapel Hill , Vaccine Trials Network , Fred Hutchinson Cancer Research Center , Human Development , Vaccine Research Center , National Institutes Of Health , Us National Institute Of Mental Health , Research For Prevention Conference , Us National Institute On Drug Abuse , National Cancer , Institute For Global Health , Sub Saharan Africa , National Institute ,

New research reveals antibody infusions can prevent HIV

The studies conducted jointly by the NIH -funded HIV Vaccine Trials Network (HVTN) and HIV Prevention Trials Network (HPTN) showed that the broadly neutralizing monoclonal HIV antibody (bNAb) VRC01, delivered intravenously once every eight weeks, was effective at preventing the acquisition of HIV strains that were sensitive to the antibody.
This was assessed by a laboratory test that measures a virus’ susceptibility to neutralization by an antibody.
Announcing the results during a press conference prior to the opening session of the meeting , Larry Corey, AMP Protocol Chair and Principal Investigator, HVTN Leadership Operations Center, based at the Fred Hutchinson Cancer Research Center, said the two proof-of-concept AMP studies demonstrated the concept that bnAb could actually prevent the acquisition of HIV infection. ....

United States , Adeeba Kamarulzaman , Roger Tatoud , Larry Corey , Leadership Operations Center , Research For Prevention , Vaccine Trials Network , Prevention Trials Network , Fred Hutchinson Cancer Research Center , Mediated Prevention , Trials Network , Principal Investigator , Operations Center , Saharan Africa , South America , Deputy Director , Vaccine Enterprise , ஒன்றுபட்டது மாநிலங்களில் , லாரி கோரி , தலைமைத்துவம் செயல்பாடுகள் மையம் , ஆராய்ச்சி க்கு ப்ரெவெந்ஶந் , தடுப்பூசி சோதனைகள் வலைப்பின்னல் , ப்ரெவெந்ஶந் சோதனைகள் வலைப்பின்னல் , ஃப்ரெட் ஹட்சின்சன் புற்றுநோய் ஆராய்ச்சி மையம் , மத்தியஸ்தம் ப்ரெவெந்ஶந் , சோதனைகள் வலைப்பின்னல் ,