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Upadacitinib Meets Endpoints in Ulcerative Colitis Maintenance Trial


Upadacitinib Meets Endpoints in Ulcerative Colitis Maintenance Trial
The upadacitinib ulcerative colitis program includes 3 pivotal studies that have enrolled more than 1300 patients with moderately to severely active ulcerative colitis. (Credit: Getty Images.)
A phase 3 study evaluating upadacitinib for the maintenance treatment of adults with moderately to severely active ulcerative colitis met its primary and all secondary endpoints.
The multicenter, randomized, double-blind, placebo-controlled maintenance study (ClinicalTrials.gov Identifier: NCT02819635) evaluated upadacitinib in 451 adults with moderately to severely active ulcerative colitis. Following an 8-week induction treatment period of upadacitinib 45mg once daily, 746 patients who achieved clinical response were randomly assigned to receive upadacitinib 15mg (n=148), 30mg (n=154), or placebo (n=149) for an additional 52 weeks.  ....

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AbbVie Says Phase 3 Ulcerative Colitis Maintenance Study Met Primary Endpoint

AbbVie Says Phase 3 Ulcerative Colitis Maintenance Study Met Primary Endpoint
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AbbVie Reports First-Quarter 2021 Financial Results


- Reports First-Quarter Diluted EPS of $1.99 on a GAAP Basis; Adjusted Diluted EPS of $2.95
- Delivers First-Quarter Net Revenues of $13.010 Billion on a GAAP Basis, an Increase of 51.0 Percent on a Reported Basis; Adjusted Net Revenues Were $12.935 Billion
- First-Quarter Global Net Revenues from the Immunology Portfolio Were $5.744 Billion, an Increase of 12.9 Percent on a Reported Basis, or 11.8 Percent on an Operational Basis; U.S. Humira Net Revenues Were $3.907 Billion, an Increase of 6.9 Percent; Internationally, Humira Net Revenues Were $960 Million, a Decrease of 8.3 Percent on a Reported Basis, or 12.6 Percent on an Operational Basis, Due to Biosimilar Competition; Global Skyrizi Net Revenues Were $574 Million; Global Rinvoq Net Revenues Were $303 Million ....

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