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Spinal Imaging Test Predicts the Likelihood of Bone Fractures in Older Men by Hannah Joy on March 17, 2021 at 11:33 AM A new study published in the Journal of Bone and Mineral Research that included 5,365 older men indicates that each of these measures are linked with a higher risk of developing hip and other fractures. Investigators found that including both measures compared with including only abdominal aortic calcification or only vertebral fractures improved the ability to predict which men were most likely to experience a hip or other fracture in the future. ‘Abdominal aortic calcification and a prevalent vertebral fracture can be simultaneously and quickly detected on standard radiographs or lateral spine bone density images.’ ....
New Drugs Hold Promise to Treat Blood, Bone Marrow Cancers by Angela Mohan on December 16, 2020 at 3:06 PM Blood Cancer Discovery. Myeloid leukemias are cancers derived from stem and progenitor cells in the bone marrow that give rise to all normal blood cells. One of the most common mutations involved in driving myeloid leukemias are found in the TET2 gene, which has been investigated for the last decade by Jaroslaw Maciejewski, MD, PhD, a practicing hematologist and chair of the Cleveland Clinic Department of Translational Hematology & Oncology Research. In the new study, Dr. Maciejewski and his collaborator in the Department of Translational Hematology & Oncology Research, Babal Kant Jha, PhD, report a new pharmacological strategy to preferentially target and eliminate leukemia cells with TET2 mutations. ....