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Epigenetic mechanism contributing to lifelong stress susceptibility discovered


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IMAGE: Eric J. Nestler, Dean for Academic and Scientific Affairs and Director of the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai and senior author of the.
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Credit: Mount Sinai Health System
An epigenetic modification that occurs in a major cell type in the brain s reward circuitry controls how stress early in life increases susceptibility to additional stress in adulthood, researchers at the Icahn School of Medicine at Mount Sinai have learned. In a study in
Nature Neuroscience, the team also reported that a small-molecule inhibitor of the enzyme responsible for this modification, currently being developed as an anti-cancer drug, was able to reverse increased vulnerability to lifelong stress in animal models. ....

New York , United States , Long Island , Ericj Nestler , Department Of Neurology At Massachusetts , Health System , Hope For Depression Research Foundation , Perelman School Of Medicine , Nash Family Department Of Neuroscience , National Institute Of Mental Health , Icahn School Of Medicine At Mount Sinai , University Of Pennsylvania , Mount Sinai Health System , Friedman Brain Institute , Icahn School Of Medicine , Icahn School , Mount Sinai , Nature Neuroscience , Hope Kronman , Nash Family Department , Nash Family Professor , Perelman School , Massachusetts General , National Institute , Mental Health , Depression Research ,