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Letters to the editor: 'Uniting Conservatives is like herding cats'


Letters to the editor: Uniting Conservatives is like herding cats
National Post
© Provided by National Post
A man is silhouetted walking past a Conservative party logo before the opening of the party s national convention in Halifax, in 2018.
‘Right-wing divisions run deep and can’t be reconciled within one party’
The Conservative party tries to be a home for everyone on the political right. That is an impossible mandate as it includes a very wide range of interpretations of what “on the right” means. Right-wing divisions run deep and can’t be reconciled within one party. There are Red Tories, centre-right moderates, fiscal conservatives, social conservatives, xenophobic nativists, and climate-change deniers or believers. ....

British Columbia , Jean Seely , Larry Baswick , Steven Narod , Reiner Jaakson , Meng Wanzhou , Daniel Kowbell , Justin Trudeau , Martinj Yaffe , Bernie Madoff , Mike Kennedy , Terence Corcoran , Paula Gordon , Herb Schultz , Jamesp Crowley , Harjit Sajjan , Darryl Dyck , Justin Trudeaus , Michael Kovrig , Rex Murphy , Meng Wenzhou , Fred Leitner , Drew Barnes , Michael Spavor , Jagmeet Singh , Shushiela Appavoo ,

Transforming immune killer T-cells into 'super soldiers' to fight against cancer


Transforming immune killer T-cells into super soldiers to fight against cancer
Creating super soldiers of specific white blood cells to boost an anti-tumor response has been shown in a series of elegant experiments by Princess Margaret researchers.
Research led by Ph.D. candidate Helen Loo Yau, Post-doctoral fellow Dr. Emma Bell and Senior Scientist Dr. Daniel D. De Carvalho describes a DNA modifying epigenetic therapy that can transform immune killer T-cells into super soldiers by boosting their ability to kill cancer cells.
Their findings could potentially enhance immunotherapy, a new paradigm in cancer treatment currently effective for a minority of cancer patients. Some patients respond well to immunotherapy, with their tumours drastically shrinking in size, but others respond only partially or not at all. Clinicians and scientists around the world are working to understand why immunotherapy only helps some patients. ....

Emma Bell , Emily Henderson , University Of Toronto , Department Of Medical Biophysics , Princess Margaret , Helen Loo Yau , Senior Scientist , Molecular Cell , Associate Professor , Medical Biophysics , Cancer Treatment , T Cell , எம்மா மணி , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , துறை ஆஃப் மருத்துவ உயிர் இயற்பியல் , ப்ரிந்ஸெஸ் மார்கரெட் , ஹெலன் லூ யா , மூத்தவர் விஞ்ஞானி , மூலக்கூறு செல் , இணை ப்ரொஃபெஸர் , மருத்துவ உயிர் இயற்பியல் , புற்றுநோய் சிகிச்சை , நோயெதிர்ப்பு சிகிச்சை , டி செல் ,

A single genetic test can identify the presence and cause of mismatch repair deficiency


A single genetic test can identify the presence and cause of mismatch repair deficiency
Researchers have developed a new integrated genetic/epigenetic DNA-sequencing protocol known as MultiMMR that can identify the presence and cause of mismatch repair (MMR) deficiency in a single test from a small sample of DNA in colon, endometrial, and other cancers. This alternative to complex, multi-step testing workflows can also determine causes of MMR deficiency often missed by current clinical tests. Their results are presented in the
Journal of Molecular Diagnostics, published by Elsevier.
MMR genes monitor and repair errors that can occur in normal cell replication and recombination. In some inherited and acquired cancers, one or more of the MMR genes are deactivated. The impact of MultiMMR is broad. Tumors with MMR deficiency respond well to new cancer immunotherapies, explains lead investigator Trevor J. Pugh, PhD, Department of Medical Biophysics, University of Toronto ....

Trevorj Pugh , Leslie Oldfield , Emily Henderson , Princess Margaret Cancer Centre , University Of Toronto , University Health Network , Ontario Institute For Cancer Research , Department Of Medical Biophysics , Molecular Diagnostics , Medical Biophysics , Ontario Institute , Cancer Research , Lead Author , Clinical Testing , லெஸ்லி ஓல்ட்ஃபீல்ட் , எமிலி ஹென்டர்சன் , ப்ரிந்ஸெஸ் மார்கரெட் புற்றுநோய் மையம் , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , பல்கலைக்கழகம் ஆரோக்கியம் வலைப்பின்னல் , ஆஂடேரியொ நிறுவனம் க்கு புற்றுநோய் ஆராய்ச்சி , துறை ஆஃப் மருத்துவ உயிர் இயற்பியல் , மூலக்கூறு பரிசோதனை , மருத்துவ உயிர் இயற்பியல் , ஆஂடேரியொ நிறுவனம் , புற்றுநோய் ஆராய்ச்சி , வழி நடத்து நூலாசிரியர் ,