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Permanent Hearing Loss Caused by Cancer Drug can be Prevented


Permanent Hearing Loss Caused by Cancer Drug can be Prevented
by Karishma Abhishek on 
May 15, 2021 at 11:56 PM
Specific receptor in cells could serve as a key to prevent permanent hearing loss in childhood cancer survivors who are being treated with the drug cisplatin, as per a study Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity, at
the University Of Alberta Faculty Of Medicine & Dentistry, published in
EMBO Reports.
Cisplatin is an incredibly effective
chemotherapeutic when it comes to treating solid tumours in children, contributing to an 80 per cent overall survival rate over five years. But the problem is its side-effects of ....

Amit Bhavsar , Department Of Medical Microbiology Immunology , University Of Alberta , Medical Microbiology , அமித் பாவ்சர் , துறை ஆஃப் மருத்துவ நுண்ணுயிரியல் நோயெதிர்ப்பு , பல்கலைக்கழகம் ஆஃப் ஆல்பர்ட்டா , மருத்துவ நுண்ணுயிரியல் ,

Scientists identify receptor in cells that could be key to preventing cancer drug-induced hearing loss


Scientists identify receptor in cells that could be key to preventing cancer drug-induced hearing loss
University of Alberta scientists have identified a receptor in cells that could be key to preventing permanent hearing loss in childhood cancer survivors who are being treated with the drug cisplatin. The researchers believe by inhibiting the receptor, they may be able to eliminate toxic side-effects from the drug that cause the hearing loss.
Cisplatin is an incredibly effective chemotherapeutic when it comes to treating solid tumors in children, contributing to an 80 per cent overall survival rate over five years, according to U of A researcher Amit Bhavsar, an assistant professor in the Department of Medical Microbiology & Immunology. The problem has always been with the side-effects. Nearly 100 per cent of patients who receive higher doses of cisplatin show some degree of permanent hearing loss. The ability to prevent this side-effect would dramatically improve the qua ....

Frederick West , Ted Allison , Amit Bhavsar , Emily Henderson , Department Of Medical Microbiology Immunology , University Of Alberta , Department Of Biological Sciences , Mental Health Institute , Children Health Research Institute , Cancer Research Institute Of Northern Alberta , Li Ka Shing Institute Of Virology , Medical Microbiology , Biological Sciences , Mental Health , Cancer Research Institute , Northern Alberta , Health Research Institute , ஃப்ரெடரிக் மேற்கு , டெட் அல்லிசன் , அமித் பாவ்சர் , எமிலி ஹென்டர்சன் , துறை ஆஃப் மருத்துவ நுண்ணுயிரியல் நோயெதிர்ப்பு , பல்கலைக்கழகம் ஆஃப் ஆல்பர்ட்டா , துறை ஆஃப் உயிரியல் அறிவியல் , மன ஆரோக்கியம் நிறுவனம் , குழந்தைகள் ஆரோக்கியம் ஆராய்ச்சி நிறுவனம் ,

Researchers pinpoint possible way to prevent permanent hearing loss caused by cancer drug


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IMAGE: University of Alberta researcher Amit Bhavsar is leading a team that has identified a receptor in cells that could be key to preventing permanent hearing loss in childhood cancer survivors.
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Credit: William Au
University of Alberta scientists have identified a receptor in cells that could be key to preventing permanent hearing loss in childhood cancer survivors who are being treated with the drug cisplatin. The researchers believe by inhibiting the receptor, they may be able to eliminate toxic side-effects from the drug that cause the hearing loss.
Cisplatin is an incredibly effective chemotherapeutic when it comes to treating solid tumours in children, contributing to an 80 per cent overall survival rate over five years, according to U of A researcher Amit Bhavsar, an assistant professor in the Department of Medical Microbiology & Immunology. The problem has always been with the side-effects. Nearly 100 per cent of patients w ....

Frederick West , Ted Allison , Amit Bhavsar , University Of Alberta , Department Of Biological Sciences , Mental Health Institute , Children Health Research Institute , Li Ka Shing Institute Of Virology , Canadian Institutes Of Health Research , Department Of Medical Microbiology Immunology , Stollery Children Hospital Foundation , Cancer Research Institute Of Northern Alberta , Medical Microbiology , Biological Sciences , Mental Health , Cancer Research Institute , Northern Alberta , Health Research Institute , Canadian Institutes , Health Research , Stollery Children , Hospital Foundation , ஃப்ரெடரிக் மேற்கு , டெட் அல்லிசன் , அமித் பாவ்சர் , பல்கலைக்கழகம் ஆஃப் ஆல்பர்ட்டா ,

Study reveals how oral antiviral drug works to attack SARS-CoV-2 virus


Study reveals how oral antiviral drug works to attack SARS-CoV-2 virus
A University of Alberta virology lab has uncovered how an oral antiviral drug works to attack the SARS-CoV-2 virus, in findings published May 10 in the
Journal of Biological Chemistry.
The researchers demonstrated the underlying mechanism of action by which the antiviral drug molnupiravir changes the viral genome, a process known as excessive mutagenesis or “error catastrophe.”
The polymerase, or replication engine of the virus, mistakes molnupiravir molecules for the natural building blocks required for viral genome replication and mixes them in. It causes the polymerase to make sloppy copies nonsense genomes that are useless and not viable.” ....

United States , Ridgeback Biotherapeutics , Emily Henderson , Department Of Medical Microbiology Immunology , Emory University In Atlanta , A University Of Alberta , World Health Organization , Medical Microbiology , Emory University , Antiviral Drug , Ars Cov 2 , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , துறை ஆஃப் மருத்துவ நுண்ணுயிரியல் நோயெதிர்ப்பு , உணர்ச்சி பல்கலைக்கழகம் இல் அட்லாண்டா , உலகம் ஆரோக்கியம் ஆர்கநைஸேஶந் , மருத்துவ நுண்ணுயிரியல் , உணர்ச்சி பல்கலைக்கழகம் ,

University of Alberta lab reveals how a much-needed oral antiviral drug confuses replication machinery of SARS-CoV-2


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University of Alberta lab reveals how a much-needed oral antiviral drug confuses replication machinery of SARS-CoV-2
A University of Alberta virology lab has uncovered how an oral antiviral drug works to attack the SARS-CoV-2 virus, in findings published May 10 in the Journal of Biological Chemistry.
The researchers demonstrated the underlying mechanism of action by which the antiviral drug molnupiravir changes the viral genome, a process known as excessive mutagenesis or “error catastrophe.”
“The polymerase, or replication engine of the virus, mistakes molnupiravir molecules for the natural building blocks required for viral genome replication and mixes them in,” explained Matthias Götte, professor and chair of the Department of Medical Microbiology & Immunology in the Faculty of Medicine & Dentistry and member of the Li Ka Shing Institute of Virology. “It causes the polymerase to make sloppy copies nonsense genomes that are usele ....

United States , Ridgeback Biotherapeutics , Raymond Schinazi , Egor Tchesnokov , Calvin Gordon , University Of Alberta , A University Of Alberta , World Health Organization , Alberta Ministry Of Jobs , Li Ka Shing Institute Of Virology , Canadian Institutes Of Health Research , Department Of Medical Microbiology Immunology , Emory School Of Medicine , Emory University In Atlanta , Us National Institutes Of Health Centers , Medical Microbiology , Emory University , Canadian Institutes , Health Research , Alberta Ministry , Health Centers , Emory School , ஒன்றுபட்டது மாநிலங்களில் , கால்வின் கோர்டந் , பல்கலைக்கழகம் ஆஃப் ஆல்பர்ட்டா , உலகம் ஆரோக்கியம் ஆர்கநைஸேஶந் ,