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Project Manager at National Research Foundation (NRF)


About The Employer:
The National Research Foundation (NRF) supports and promotes research and human capital development through funding, the provision of National Research Facilities and science outreach platforms and programmes to the broader community in all fields of science and technology, including natural sciences, engineering, social sciences and humanities.
The South African Radio Astronomy Observatory (SARAO) spearheads South Africa’s activities in the Square Kilometre Array Radio Telescope, commonly known as the SKA, in engineering, science and construction. SARAO is a National Facility managed by the National Research Foundation and incorporates radio astron-omy instruments and programmes such as the MeerKAT and KAT-7 telescopes in the Karoo, the Harte-beesthoek Radio Astronomy Observatory (HartRAO) in Gauteng, the African Very Long Baseline Interferom-etry (AVN) programme in nine African countries as well as the associated human capital development and com ....

South Africa , National Research Facilities , National Research Foundation , National Facility , Management Office , Project Management , Managing Engineering , Systems Engineering , South African Radio Astronomy Observatory , Square Kilometre Array Radio Telescope , Harte Beesthoek Radio Astronomy Observatory , African Very Long Baseline Interferom Etry , தேசிய ஆராய்ச்சி வசதிகள் , தேசிய ஆராய்ச்சி அடித்தளம் , தேசிய வசதி , மேலாண்மை அலுவலகம் , ப்ராஜெக்ட் மேலாண்மை , நிர்வகித்தல் பொறியியல் , அமைப்புகள் பொறியியல் , சதுரம் கிலோமீடர் வரிசை வானொலி தொலைநோக்கி ,

Metabolically engineered stem cell–derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis


Abstract
Despite the remarkable advances in therapeutics for rheumatoid arthritis (RA), a large number of patients still lack effective countermeasures. Recently, the reprogramming of macrophages to an immunoregulatory phenotype has emerged as a promising therapeutic strategy for RA. Here, we report metabolically engineered exosomes that have been surface-modified for the targeted reprogramming of macrophages. Qualified exosomes were readily harvested from metabolically engineered stem cells by tangential flow filtration at a high yield while maintaining their innate immunomodulatory components. When systemically administered into mice with collagen-induced arthritis, these exosomes effectively accumulated in the inflamed joints, inducing a cascade of anti-inflammatory events via macrophage phenotype regulation. The level of therapeutic efficacy obtained with bare exosomes was achievable with the engineered exosomes of 10 times less dose. On the basis of the boosted nature to ....

United States , Soult Ukpyolsi , South Korea , Castillay Leóp , Republic Of Korea , Takara Bio , Exosomes Exos , Leica Biosystems , Bioanalyzer Santa Clara , Analyte Elisarray , Exos Msc , Korea Basic Science Institute National Research Facilities , Younglin Co , Science Research Programs , Korea Basic Science Institute , Agilent Technologies , National Research Foundation , Sungkyunkwan University , Central Lab Animal Inc , Ministry Of Health Welfare , Exostemtech Inc , Aldrich Co , Ministry Of Education , Equipment Center , Hyclone Laboratories Inc , Spectrum Laboratories Inc ,

Generating electricity from heat using the spin Seebeck device


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IMAGE: (Left) Structure of conventional thermoelectric module based on charge Seebeck effect
(Right) Structure of new thermoelectric module based on spin Seebeck effect
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Credit: POSTECH
Thermoelectric (TE) conversion offers a carbon-free power generation from geothermal, waste, body or solar heat, and shows promise to be the next-generation energy conversion technology. At the core of such TE conversion, there lies an all solid-state thermoelectric device which enables energy conversion without the emission of noise, vibrations, or pollutants. To this, a POSTECH research team proposed a way to design the next-generation thermoelectric device that exhibits remarkably simple manufacturing process and structure compared to the conventional ones, while displaying improved energy conversion efficiency using the spin Seebeck effect (SSE).1 ....

South Korea , Young Kim , Hyungyu Jin , Si Young Choi , National Research Facilities , Department Of Mechanical Engineering , Department Of Materials Science , Young Researcher Program , Strategic International Collaborative Research Program , Professor Hyungyu Jin , Min Young Kim , Mechanical Engineering , Professor Si Young Choi , Materials Science , Environmental Science , Global Frontier Hybrid Interface Materials , National Research Foundation , Equipment Center Program , Korea Basic Science , Chemistry Physics Materials Sciences , Energy Fuel Non Petroleum , Energy Sources , Technology Engineering Computer Science , Electrical Engineering Electronics , Research Development , தெற்கு கொரியா ,