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In surprising twist, some Alzheimer's plaques may be protective, not destructive

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IMAGE: A dense-core amyloid-beta plaque (red) surrounded by microglia that lack TAM receptors (white) in the brain of a mouse with Alzheimer s disease
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Credit: Salk Institute
LA JOLLA (April 15, 2021) One of the characteristic hallmarks of Alzheimer s disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but they ve largely failed in clinical trials. New research by Salk scientists upends conventional views of the origin of one prevalent type of plaque, indicating a reason why treatments have been unsuccessful.
The traditional view holds that the brain s trash-clearing immune cells, called microglia, inhibit the growth of plaques by eating them. The Salk scientists show instead that microglia promote the formation of dense-core plaques, and that this action sweeps wispy plaque material away from neurons, where it causes cell death. The research, which was publi ....

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Rotary Club of Palm Coast raises funds for Alzheimer's research

Rotary Club of Palm Coast raises funds for Alzheimer's research
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Protein in cerebrospinal fluid signals Alzheimer's stage

A new form of an Alzheimer’s disease protein in the fluid that surrounds the brain and spinal cord indicates what stage of the disease a person is in, and tracks with tangles of tau protein in the brain, according to a new study.
Tau tangles are thought to be toxic to neurons, and their spread through the brain foretells the death of brain tissue and cognitive decline. Tangles appear as the early, asymptomatic stage of Alzheimer’s develops into the symptomatic stage.
The discovery of so-called microtubule binding region tau (MTBR tau) in the cerebrospinal fluid could lead to a way to diagnose people in the earliest stages of Alzheimer’s disease, before they have symptoms or when their symptoms are still mild and easily misdiagnosed. ....

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