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Farshid Guilak, PhD, named Kappa Delta Elizabeth Winston Lanier Award recipient for research in functional cartilage engineering for total joint resurfacing


Farshid Guilak, PhD, named Kappa Delta Elizabeth Winston Lanier Award recipient for research in functional cartilage engineering for total joint resurfacing
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ROSEMONT, Ill., Feb. 12, 2021 /PRNewswire/ The 2021 Kappa Delta Elizabeth Winston Lanier Award was presented to Farshid Guilak, PhD and his co-authors, Bradley T. Estes, PhD, and Franklin T. Moutos, PhD, for their research and development of technology to grow bioartificial cartilage using a patient s own donor cells and seeding them on a novel scaffold that can be molded to match the shape of a patient s joint. Following a successful preclinical trial on canines with hip osteoarthritis (OA), the research is soon expected to begin a Phase I clinical trial. Additionally, Dr. Guilak s work in gene therapy to protect against joint inflammation has the potential to advance the treatment of patients with arthritis and some orthopaedic conditions. The Kappa Del ....

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'Smart' cartilage cells programmed to release drugs when stressed | The Source | Washington University in St. Louis


New technology could lead to treatments for osteoarthritis
January 27, 2021
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Researchers at Washington University School of Medicine in St. Louis have engineered cartilage cells to release an anti-inflammatory drug in response to stresses such cells undergo when they are compressed during weight bearing and movement. Here, the cell, called a chondrocyte, is stimulated with a very small glass pipette, about 1/5 the diameter of a human hair. When these cells undergo compression, they release the drug that combats inflammation. (Image: Guilak lab)
Working to develop new treatments for osteoarthritis, researchers at Washington University School of Medicine in St. Louis have genetically engineered cartilage to deliver an anti-inflammatory drug in response to activity similar to the bending of a knee or other motions that put stress on joints. ....

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Shriners Hospitals for Children study reveals new link to arthritis


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IMAGE: Lead author of the study, Dr. Kelsey Collins is a postdoctoral fellow in Guilak s laboratory.
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Credit: Shriners Hospitals for Children
(St. Louis) - A new study by investigators at the Shriners Hospital for Children St. Louis suggests the damaging effects of obesity are not due to body weight but rather come from something much smaller - biochemical signals released by fat cells.
The study focuses on the link between overweight or obesity and the development of osteoarthritis, a painful disease of the joints. The investigation was led by Dr. Farshid Guilak, director of the St. Louis Shriners Hospital Research Center. ....

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