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"Dexmedetomidine for hyperactive delirium at the end of life: An open-l" by Benjamin Thomas, Wing Shan Angela Lo et al.


Abstract
Background: Terminal delirium, specifically the hyperactive delirium subtype at the end of life, is common in palliative care patients. Standard care often involves sedation to alleviate distress. The alpha -adrenoreceptor agonist dexmedetomidine may have promise in terminal delirium, due to its properties of decreasing delirium and permitting rousable sedation. Aim: This study aimed to describe the effect of dexmedetomidine on delirium and sedation, when delivered via continuous subcutaneous infusion (CSCI) in patients with terminal delirium. Design: The trial was prospectively registered in the ANZCTR database (ACTRN12618000658213) and conducted in accordance with CONSORT (pilot study extension). Twenty-two adult patients were treated with a CSCI of dexmedetomidine with a two-tier dose schedule, low and high dose. Delirium severity was measured by the Memorial Delirium Assessment Scale (MDAS, target ....

Memorial Delirium Assessment Scale , Richmond Agitation Sedation Scale , Palliative Version , Conscious Sedation , Ypnotics And Sedatives , Pilot Projects , Terminal Care , நினைவகம் மயக்கம் மதிப்பீடு அளவு , உணர்வு மயக்கம் ,