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Alzheimer protein APP regulates learning and social behavior in the healthy brain


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IMAGE: Lack of the APP family leads to abnormal positioning of neurons (yellow) in the hippocampus. Neurons lacking APP family proteins show fewer synaptic connections.
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Credit: Susanne Klein, Prof. Müller s research group, Heidelberg University
While the APP protein is well-known for its key role in Alzheimer s disease, its contribution to healthy brain function, by contrast, has remained largely unknown until now. Recently, an international research team, led by molecular biologist Prof. Dr Ulrike Müller from Heidelberg University, gained new insights on the physiological functions of the APP protein family by using a mouse model lacking APP. The absence of APP during brain development was shown to result in the malformation of important brain regions implicated in learning and memory. Consequently, these mice were severely impaired in their learning abilities and exhibited autistic-like behaviour. ....

Baden Wüberg , Technische Universit , University Of Mainz , German Research Foundation , University Of Zurich Switzerland , Molecular Biotechnology Of Heidelberg University , Institute Of Pharmacy , Heidelberg University , Functional Genomics , Molecular Biotechnology , Molecular Biology , Alzheimers Disease , ஜெர்மன் ஆராய்ச்சி அடித்தளம் , பல்கலைக்கழகம் ஆஃப் ஸுரி சுவிட்சர்லாந்து , நிறுவனம் ஆஃப் மருந்தகம் , ஹைடெல்பெர்க் பல்கலைக்கழகம் , செயல்பாட்டு மரபியல் , மூலக்கூறு உயிரி தொழில்நுட்பவியல் ,

Värska mineral water in Estonia turned into a throat spray

Värska mineral water in Estonia turned into a throat spray
estonianworld.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from estonianworld.com Daily Mail and Mail on Sunday newspapers.

Einar Raudkepp , Vladimir Tassa , Enn Karro , Institute Of Pharmacy , Researchers Of The University Tartu , Ain Raal , Setomaa Parish , Water Park , நிறுவனம் ஆஃப் மருந்தகம் , தண்ணீர் பூங்கா ,

New inhibitor found to combat drug-resistant cancer cells


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A new substance could improve the treatment of persistent cancers. Researchers at Martin Luther University Halle-Wittenberg (MLU) and the University of Greifswald have developed a new inhibitor that makes drug-resistant tumour cells respond again to chemotherapy. The new substance blocks a protein in the cancer cells that normally transports the cancer drugs back out of the cells. The results were published in the scientific journal
Molecules.
In addition to radiation therapy, cytotoxic agents, also known as chemotherapy, are frequently used to treat cancer. They prevent cells from dividing and thus cancer cells are unable to multiply unchecked. Cytotoxic agents remain a very important form of treatment because they have a general effect, in other words, they work on different types of cancer, explains Dr Andreas Hilgeroth, a professor of pharmacy at MLU. However, some tumours are resistant to chemotherapy. They possess certain proteins that transport the d ....

Christoph Ritter , Andreas Hilgeroth , University Of Greifswald , Institute Of Pharmacy , Researchers At Martin Luther University Halle Wittenberg , Martin Luther University Halle Wittenberg , Professor Christoph Ritter , Pharmaceutical Sciences , Medicine Health , Pharmaceutical Science , Pharmaceutical Chemistry , கிறிஸ்டோஃப் ரிடர் , பல்கலைக்கழகம் ஆஃப் க்ரீஃப்ஸ்‌வால்ட் , நிறுவனம் ஆஃப் மருந்தகம் , ஆராய்ச்சியாளர்கள் இல் மார்டின் லூதர் பல்கலைக்கழகம் ஹால் விட்டன்பெர்க் , மார்டின் லூதர் பல்கலைக்கழகம் ஹால் விட்டன்பெர்க் , ப்ரொஃபெஸர் கிறிஸ்டோஃப் ரிடர் , மருந்து அறிவியல் , மருந்து ஆரோக்கியம் , மருந்து வேதியியல் ,