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High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

Excessive inflammation is a characteristic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, particularly in patients that are hospitalized with coronavirus disease 2019 (COVID-19). Here, Hoepel et al. investigated how human antibodies specific to SARS-CoV-2 spike protein may contribute to exacerbated inflammation. The authors found that spike protein–specific antibodies from patients with COVID-19 who were hospitalized had altered glycosylation, with an enrichment in low-fucosylated antibodies. These antibodies were able to activate human macrophages in vitro to secrete proinflammatory cytokines. Thus, altered antibody glycosylation may contribute to disease severity in COVID-19.

Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show ....

Noord Holland , United States , Miltenyi Biotec , U Cytech Biosciences , Melinda Gates Foundation , Dutch Federation Of University Medical Centers , Innovative Medicines Initiative , Amsterdam Cardiovascular Sciences , Agilent Technologies , Dutch Heart Foundation , Netherlands Organization For Health Research , European Union , Graphpad Software , Discovery Workbench Software , European Union Horizon , Proinflammatory Panel , European Commission , Vrije Universiteit Medical Center , Transatlantic Network Grant , Ethical Committee , Netherlands Cardiovascular Research Initiative , Netherlands Heart Foundation , Sanquin Blood Supply Foundation , Royal Netherlands Academy Of Sciences , Chemokine Panel , Biomarker Group ,

Vagus nerve stimulation: a potential new treatment for ischaemic stroke

Vagus nerve stimulation: a potential new treatment for ischaemic stroke
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Jesse Dawson , Netherlands Heart Foundation , Elsevier Ltd , Netherlands Scientific Organisation Vidi , Fugl Meyer Assessment Upper Extremity , View Large , Netherlands Scientific Organisation , ஜெஸ்ஸி டாசன் , நெதர்லாந்து இதயம் அடித்தளம் , பார்வை பெரியது ,

Gene discovery could help prevent heart attacks

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IMAGE: Researcher Mete Civelek, PhD, of the University of Virginia School of Medicine s Department of Biomedical Engineering and UVA s Center for Public Health Genomics.
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Credit: Courtesy Civelek lab
Researchers at the University of Virginia have shed light on how our genes affect our risk for coronary artery disease, the most common form of heart disease. In addition to identifying gene variants that influence risk, they found that one gene in particular appears to have a protective effect.
Doctors may be able to use the findings to identify people at high risk and to develop better treatments and preventative interventions. ....

United States , The Netherlands , Alanm Fogelman , Gerard Pasterkamp , Aaron Aguhob , Garyk Owens , Ngozi Akingbesote , Liang Guo , Rita Anane , Mohamad Navab , Juditha Berliner , Emily Farber , Arjan Boltjes , Minnau Kaikkonen , Jameson Hinkle , Aloke Finn , Johanlm Bjorkegren , Alisa Chen , Bruin Pharma , Gabrielf Alencar , Clintl Miller , Lijiang Ma , Suna Onengut Gumuscu , Innovation Programme , School Of Medicine , American Heart Association Postdoctoral Fellowship ,

UVA researchers identify genes that influence risk for common form of heart disease

UVA researchers identify genes that influence risk for common form of heart disease
Dec 10 2020
Researchers at the University of Virginia have shed light on how our genes affect our risk for coronary artery disease, the most common form of heart disease. In addition to identifying gene variants that influence risk, they found that one gene in particular appears to have a protective effect.
Doctors may be able to use the findings to identify people at high risk and to develop better treatments and preventative interventions.
Current drugs for coronary artery disease treat the risk factors, such as cholesterol or hypertension. Our studies used a genetic approach to identify the mechanisms in the wall of the blood vessels where the disease actually develops.” ....

United States , The Netherlands , Alanm Fogelman , Gerard Pasterkamp , Aaron Aguhob , Garyk Owens , Ngozi Akingbesote , Liang Guo , Rita Anane , Mohamad Navab , Juditha Berliner , Emily Farber , Arjan Boltjes , Minnau Kaikkonen , Jameson Hinkle , Aloke Finn , Johanlm Bjorkegren , Alisa Chen , Bruin Pharma , Gabrielf Alencar , Clintl Miller , Lijiang Ma , Suna Onengut Gumuscu , Innovation Programme , School Of Medicine , American Heart Association Postdoctoral Fellowship ,